Clinical and genetic features of familial pituitary adenomas.

Adenoma/etiology/genetics/pathology; Animals; Humans; Mice; Mice, Knockout; Multiple Endocrine Neoplasia Type 1/etiology/genetics/pathology; Pituitary Neoplasms/complications/genetics/pathology; pituitary; tumor; adenoma; familial

Abstract :

[en] Inherited or familial pituitary tumor syndromes such as multiple endocrine neoplasia type 1 and Carney complex provide an important insight into the genetics and molecular pathology of endocrine cancers. Our understanding of these conditions is expanding rapidly due to the identification of the genes and proteins affected and the availability of murine knockout models. The successes achieved to date in understanding multiple endocrine neoplasia type 1 and Carney complex have helped in the identification and study of new inherited pituitary tumor syndromes such as isolated familial somatotropinomas. This review assesses the current status of research into the clinical features, genetics and molecular pathologies of multiple endocrine neoplasia type 1, Carney complex, and isolated familial somatotropinomas, and details ongoing work to delineate familial isolated pituitary adenomas, a potentially new clinical entity.

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Daly, Adrian ; Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie

Jaffrain-Rea, M. L.

Beckers, Albert ; Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie

Language :

English

Title :

Clinical and genetic features of familial pituitary adenomas.

Publication date :

2005

Journal title :

Hormone and Metabolic Research

ISSN :

0018-5043

eISSN :

1439-4286

Publisher :

Georg Thieme Verlag Stuttgart, Stuttgart, Germany

Volume :

Issue :

Pages :

347-54

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 21 June 2010

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