Article (Scientific journals)
Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units
Delanaye, Pierre; Lambermont, Bernard; Chapelle, Jean-Paul et al.
2004In Intensive Care Medicine, 30 (5), p. 980-983
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Keywords :
creatinine; critical care; cystatin C; glomerular filtration rate; kidney function tests
Abstract :
[en] OBJECTIVE: To compare the sensitivity of cystatin C and creatinine in detecting decreased glomerular filtration rate. DESIGN: Prospective observational study. SETTING: Medical intensive care unit at a university hospital. PATIENTS AND PARTICIPANTS: Fourteen patients hospitalised in a medical intensive care unit. INTERVENTIONS: Cystatin C and creatinine plasmatic levels were measured in 40 blood samples taken with an interval of at least 24 h. MEASUREMENTS AND RESULTS: Glomerular filtration rate was estimated by creatinine clearance using 24-h urine collection and the classical Cockcroft-Gault equation. The ability of cystatin C to detect a glomerular filtration rate under 80 ml/min per 1.73 m(2) was significantly better than that of creatinine ( p<0.05). CONCLUSIONS: Cystatin C, a new plasmatic marker of renal function, could be used to detect renal failure in intensive care in the future.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Delanaye, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
Lambermont, Bernard  ;  Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine
Chapelle, Jean-Paul ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Gielen, Jacques
Gérard, Paul ;  Université de Liège - ULiège > Département de mathématique > Statistique (aspects expérimentaux)
Rorive, Georges ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Language :
English
Title :
Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units
Publication date :
May 2004
Journal title :
Intensive Care Medicine
ISSN :
0342-4642
eISSN :
1432-1238
Publisher :
Springer-Verlag, New York, United States - New York
Volume :
30
Issue :
5
Pages :
980-983
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
All our thank to Springer Verlag. The original publication is available at www.springerlink.com
Available on ORBi :
since 16 February 2009

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