Article (Scientific journals)
Liver transplantation in Jehovah's witnesses
Detry, Olivier; De Roover, Arnaud; Delwaide, Jean et al.
2005In Transplant International, 18 (8), p. 929-936
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Keywords :
coagulation; complication; haemorrhage; Jehovah; liver transplantation; living donor; surgery; transfusion
Abstract :
[en] For religious reasons, Jehovah's witnesses refuse transfusion of blood products (red cells, platelets, plasma), but may accept organ transplantation. The authors developed a multidisciplinary protocol for liver transplantation in Jehovah's witnesses. In a 6-year period, nine Jehovah's witness patients were listed for liver transplantation. They received preoperative erythropoietin therapy, with iron and folic acid that allowed significant haematocrit increase. Two patients underwent partial spleen embolization to increase platelet count. Seven patients underwent cadaveric whole liver transplantation, and two right lobe living-related liver transplantation, using continuous circuit cell saving system and high dose aprotinin. No patient received any blood product during the surgical procedure. One patient suffering from deep anaemia after living-related liver transplantation was transfused as required by his family, but died from aspergillus infection. One 6-year-old child was transfused against her parent's will. The authors demonstrated that it is possible to increase haematocrit and platelet levels in cirrhotic patients awaiting liver transplantation. They were able to reduce intraoperative need for blood products, allowing liver transplantation in prepared Jehovah's witness patients. This experience may be beneficial for non-Jehovah's witness liver transplant recipients.
Disciplines :
Surgery
Gastroenterology & hepatology
Author, co-author :
Detry, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
De Roover, Arnaud ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Delwaide, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Kaba, Abdourahmane ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Joris, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Damas, Pierre ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Lamy, Maurice ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Honore, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Meurisse, Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Chirurgicale abdominale
Language :
English
Title :
Liver transplantation in Jehovah's witnesses
Publication date :
August 2005
Journal title :
Transplant International
ISSN :
0934-0874
eISSN :
1432-2277
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
18
Issue :
8
Pages :
929-936
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 September 2008

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