Dynamics of skin barrier repair following topical applications of miconazole nitrate.

Administration, Topical; Adult; Body Water/metabolism; Double-Blind Method; Humans; Miconazole/administration & dosage; Middle Aged; Skin/drug effects/metabolism

Abstract :

[en] The skin barrier function (SBF) is an important aspect of skin biology, particularly in the elicitation of inflammation. The SBF recovery rate after tape stripping and surfactant challenge can be assessed by measuring the transepidermal water loss (TEWL). Previous clinical studies have shown some inflammatory effect after topical applications of miconazole. The aim of this study was to compare the effect of pastes (petrolatum and 15% zinc oxide) containing or not miconazole nitrate on controlled impaired SBF. Fifteen volunteers were enrolled. In each subject, successive cyanoacrylate skin surface strippings were harvested from 5 sites of the volar forearm until TEWL raised above 15 g/cm(2)/h on all test sites. In addition, one daily soak session with a 0.2% dishwashing liquid further damaged the SBF. Each of the test formulations was applied twice daily for 5 days at two dosages, namely 1 and 2 mg/cm(2), on randomized test sites. Another site remained untreated. TEWL was measured daily for 5 days. A fastened SBF repair was observed on all treated sites, particularly where the largest amount of the products had been applied. A faster SBF recovery rate was obtained at the site receiving the miconazole nitrate paste. We conclude that the occlusive effect of a paste helped mitigate SBF defect. The adjunction of miconazole nitrate improved the efficacy. Copyright (c) 2006 S. Karger AG, Basel.

Disciplines :

Dermatology

Author, co-author :

Xhauflaire, Emmanuelle ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Vroome, Valérie; Barrier Therapeutics, N.B., Geel, Belgium

Cauwenbergh, G.; Barrier Therapeutics, Geel, Belgium

Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Language :

English

Title :

Dynamics of skin barrier repair following topical applications of miconazole nitrate.

Publication date :

2006

Journal title :

Skin Pharmacology and Physiology

ISSN :

1660-5527

eISSN :

1660-5535

Publisher :

S. Karger, Basel, Switzerland

Volume :

Issue :

Pages :

290-4

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 13 February 2009

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