[en] The difficulty of establishing structure-activity relationships in the beta-lactam family of antibiotics stems from the fact that: (1) The targets in various bacteria exhibit widely different sensitivities. (2) Some bacteria produce beta-lactamases, enzymes capable of destroying the antibiotics. The rates of the reactions with the beta-lactamases and the target enzymes are not necessarily related. (3) In Gram-negative bacteria, the diffusion rate through the outer membrane varies independently from the two other factors.
Disciplines :
Biochemistry, biophysics & molecular biology Chemical engineering
Author, co-author :
Frère, Jean-Marie ; Université de Liège - ULiège > Département des sciences de la vie > Département des sciences de la vie
Joris, Bernard ; Université de Liège - ULiège > Centre d'ingénierie des protéines
Varetto, Louis ; Université de Liège - ULiège > Département des sciences de la vie > Département des sciences de la vie
Crine, Michel ; Université de Liège - ULiège > Département de chimie appliquée > Génie chimique - Opérations physiques unitaires
Language :
English
Title :
Structure-Activity Relationships in the Beta-Lactam Family: An Impossible Dream
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