Relationship between structural properties and affinity for herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2'-deoxyuridines
[en] The crystal structures of 5-(5-furan-2-yl)-2'-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2' deoxyuridine (IV) and 5-(3-bromothien-2-yl)-2'-deoxyuridine (V) have been studied in order to explain the different affinity of the compounds for the herpes simplex virus type 1 (HSV-1) thymidine kinase. These compounds present a variable affinity according to the position of the heteroatom substituting the five-membered ring. An unfavourable substitution in the five-membered ring for interaction with the HSV-1 thymidine kinase has been identified.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Creuven, Isabelle; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Département de Chimie > Laboratoire de Chimie Moléculaire Structurale
Evrard, Christine ; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Département de Chimie > Laboratoire de Chimie Moléculaire Structurale
Olivier, Anne; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Département de Chimie > Laboratoire de Chimie Moléculaire Structurale
Evrard, Guy; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Département de Chimie > Laboratoire de Chimie Moléculaire Structurale
Van Aerschot, Arthur; Katholieke Universiteit Leuven - KUL
Wigerinck, Piet; Katholieke Universiteit Leuven - KUL
Herdewijn, Piet; Katholieke Universiteit Leuven - KUL
Durant, François; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Département de Chimie > Laboratoire de Chimie Moléculaire Structurale
Language :
English
Title :
Relationship between structural properties and affinity for herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2'-deoxyuridines
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