Healing effect of ketanserin on chronic leg ulcers in patients with diabetes.

Administration, Cutaneous; Aged; Chronic Disease; Diabetes Mellitus, Type 1; Diabetic Foot/drug therapy/pathology; Double-Blind Method; Female; Humans; Keratolytic Agents/administration & dosage/therapeutic use; Ketanserin/administration & dosage/therapeutic use; Leg Ulcer/drug therapy/pathology; Middle Aged; Serotonin Antagonists/administration & dosage/therapeutic use; Severity of Illness Index; Treatment Outcome; Wound Healing

Abstract :

[en] BACKGROUND: The treatment of chronic leg ulcers remains a stubborn problem in many patients. Topical 2% ketanserin ointment, a 5HT2-serotoninergic blocking agent, has been reported to improve healing of decubitus, venous, diabetic and ischaemic ulcers. METHOD: The present double-blind intra-individual comparative study was performed in 12 women with diabetes presenting with at least two similar leg ulcers. In each subject, the two lesions were randomly assigned to be treated for 8 weeks by 2% ketanserin ointment or its unmedicated vehicle. OBJECTIVE: assessments of the dynamics of wound healing were performed using computerized morphometry. Evaluations were performed at 2-week intervals for 8 weeks. RESULTS: A significant decrease in relative wound area was observed on the ketanserin-treated ulcers compared with the placebo group. CONCLUSION: Topical ketanserin is a valuable therapy for difficult-to-treat leg ulcers.

Disciplines :

Dermatology

Author, co-author :

Quatresooz, Pascale ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Kharfi, M.; Centre Hospitalier Universitaire de Rouen, Hôpital Charles Nicolle > Dermatologie

Paquet, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Vroome, V.

Cauwenbergh, G.

Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Language :

English

Title :

Healing effect of ketanserin on chronic leg ulcers in patients with diabetes.

Publication date :

2006

Journal title :

Journal of the European Academy of Dermatology and Venereology

ISSN :

0926-9959

eISSN :

1468-3083

Publisher :

Blackwell Publishing, Oxford, United Kingdom

Volume :

Issue :

Pages :

277-81

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 11 February 2009

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