Healing effect of ketanserin on chronic leg ulcers in patients with diabetes.

Administration, Cutaneous; Aged; Chronic Disease; Diabetes Mellitus, Type 1; Diabetic Foot/drug therapy/pathology; Double-Blind Method; Female; Humans; Keratolytic Agents/administration & dosage/therapeutic use; Ketanserin/administration & dosage/therapeutic use; Leg Ulcer/drug therapy/pathology; Middle Aged; Serotonin Antagonists/administration & dosage/therapeutic use; Severity of Illness Index; Treatment Outcome; Wound Healing

Abstract :

[en] BACKGROUND: The treatment of chronic leg ulcers remains a stubborn problem in many patients. Topical 2% ketanserin ointment, a 5HT2-serotoninergic blocking agent, has been reported to improve healing of decubitus, venous, diabetic and ischaemic ulcers. METHOD: The present double-blind intra-individual comparative study was performed in 12 women with diabetes presenting with at least two similar leg ulcers. In each subject, the two lesions were randomly assigned to be treated for 8 weeks by 2% ketanserin ointment or its unmedicated vehicle. OBJECTIVE: assessments of the dynamics of wound healing were performed using computerized morphometry. Evaluations were performed at 2-week intervals for 8 weeks. RESULTS: A significant decrease in relative wound area was observed on the ketanserin-treated ulcers compared with the placebo group. CONCLUSION: Topical ketanserin is a valuable therapy for difficult-to-treat leg ulcers.

Disciplines :

Dermatology

Author, co-author :

Quatresooz, Pascale ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Kharfi, M.; Centre Hospitalier Universitaire de Rouen, Hôpital Charles Nicolle > Dermatologie

Paquet, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Vroome, V.

Cauwenbergh, G.

Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Language :

English

Title :

Healing effect of ketanserin on chronic leg ulcers in patients with diabetes.

Publication date :

2006

Journal title :

Journal of the European Academy of Dermatology and Venereology

ISSN :

0926-9959

eISSN :

1468-3083

Publisher :

Blackwell Publishing, Oxford, United Kingdom

Volume :

Issue :

Pages :

277-81

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 11 February 2009

Statistics

Number of views

109 (4 by ULiège)

Number of downloads

6 (1 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Singer AJ, Clark RAF. Cutaneous wound healing. N Engl J Med 1999; 341: 738-746.
Quatresooz P, Henry F, Paquet P et al. Deciphering the impaired cytokine cascades in chronic leg ulcers. Int J Mol Med 2003; 11: 411-418.
Janssen PAJ, Janssen H, Cauwenbergh G et al. Use of topical ketanserin in the treatment of skin ulcers: A double-blind study. J Am Acad Dermatol 1989; 21: 85-90.
Awouters F. The pharmacology of ketanserin, the first selective serotonin S2-antagonist. Drug Dev Res 1985; 6: 263-300.
Gilman TH. Parameter for measurement of wound closure. Wounds 1990; 3: 95-101.
Deleixhe-Mauhin F, Piérard GE, Piérard-Franchimont C et al. A morphometric analysis of the healing rate of ulcerations on atrophie blanche during simple nursing care. Eur J Dermatol 1991; 1: 101-104.
Margolis DJ, Gross EA, Wood CR et al. Planimetric rate of healing in venous ulcers of the leg treated with pressure bandage and hydrocolloid dressing. J Am Acad Dermatol 1993; 28: 418-421.
Piérard GE, Piérard-Franchimont C. Planimetry of the healing rate of leg ulcers. Eur J Dermatol 1995; 5: 257-262.
Piérard-Franchimont C, Paquet R, Arrese JE et al. Healing rate and bacterial necrotizing vasculitis in venous leg ulcers. Dermatology 1997; 194: 383-387.
Paquet P, Quatresooz P, Braham C et al. Tapping into the influence of keratinocyte allografts and biocenosis on healing of chronic leg ulcers: A split-ulcer controlled pilot study. Dermatol Surg 2005; 31: 431-435.
Fumal I, Braham C, Paquet P et al. The beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora: A proof-to-concept study. Dermatology 2002; 204: S79-S85.
Tooke JE, McGibney D. Serotonin (S22) antagonism and microvascular haemodynamics in diabetics with foot ulceration. Clin Sci 1982; 63: 28.
Vitug AC, Schneider SH, Khachadurian AK. Effects of a serotonin-S2 antagonist on total and nutritive blood flow in the diabetic foot. Clin Res 1986; 34: 867A.
De Ridder I, Beele H. Immediate effects of serotonin and ketanserin on embryonic chick skin in vitro. Experientia 1988; 44: 603-606.
Cordts PR, Hanrahan LM, Rodriguez AA et al. A prospective randomized trial of Unna's boot versus duoderm CGF hydroactive dressing plus compression in the management of venous leg ulcers. J Vasc Surg 1992; 15: 480-486.
Pecoraro RE, Ahroni JH, Boyko EJ et al. Chronology and determinants of tissue repair in diabetic lower extremity ulcers. Diabetes 1991; 40: 1305-1313.
Margolis DJ, Gross EA, Wood CR et al. Planimetric rate of healing in venous ulcers of the leg treated with pressure bandage and hydrocolloid dressing. J Am Acad Dermatol 1993; 28: 418-421.