Cooperative 2:1 Binding of a Bisphenothiazine to Duplex DNA

Rosu, Frédéric; Gabelica, Valérie; De Pauw, Edwin; Mailliet, Patrick; Mergny, Jean-Louis

doi:10.1002/cbic.200700572

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Cooperative 2:1 Binding of a Bisphenothiazine to Duplex DNA

Rosu, Frédéric; Gabelica, Valérie; De Pauw, Edwin et al.

2008 • In Chembiochem: A European Journal of Chemical Biology, 9, p. 849-852

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/606

DOI
10.1002/cbic.200700572

PubMed
18307188

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Keywords :

mass spectrometry; DNA; noncovalent interactions; binding mode; SPR; molecular modeling

Abstract :

[en] Highly cooperative formation of a 2:1 complex was revealed by electrospray mass spectrometry experiments, and a structural model is proposed.

Research Center/Unit :

Giga-Systems Biology and Chemical Biology - ULiège

Disciplines :

Chemistry
Biochemistry, biophysics & molecular biology

Author, co-author :

Rosu, Frédéric ; Université de Liège - ULiège > Département de chimie (Sciences) > Chimie physique, spectrométrie de masse

Gabelica, Valérie ; Université de Liège - ULiège > Département de chimie (Sciences) > Chimie physique, spectrométrie de masse

De Pauw, Edwin ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie physique, spectrométrie de masse

Mailliet, Patrick; Sanofi-Aventis > Centre de Recherches de Paris

Mergny, Jean-Louis; Museum National dHistoire Naturelle, Paris - MNHN > USM503, CNRS UMR 5153, INSERM U565 > Acides Nucl8iques: Dynamique, Ciblage et Fonction Biologiques

Language :

English

Title :

Cooperative 2:1 Binding of a Bisphenothiazine to Duplex DNA

Publication date :

2008

Journal title :

Chembiochem: A European Journal of Chemical Biology

ISSN :

1439-4227

eISSN :

1439-7633

Publisher :

Wiley-VCH Verlag Gmbh, Weinheim, Germany

Volume :

Pages :

849-852

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.interscience.wiley.com/

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Commentary :

This is a preprint of an article published in ChemBioChem (2008), 9, 849-852.

Available on ORBi :

since 16 September 2008

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