[en] Background: aneurysmal disease is associated with all inflammatory Cell infiltrate and enzymatic degradation of the vessel wall. Aim of the study: to detect increased metabolic activity in abdominal aortic aneurysms (AAA) by means of positron emission tomography (PET-imaging). Study design: twenty-six patients with AAA underwent PET-imaging Results: in tell patients, PET-imaging revealed increased, fluoro-deoxy-glucose (18-FDG) uptake at the level of the aneurysm. Patients with positive PET-imaging had one or more of the following elements in their clinical history: history Of recent non-aortic surgery (n = 4) a painful inflammatory aortic aneurysm (n = 2). moderate low back pain (n = 2), rapid (>5 mm in 6 months) expansion (n = 4), discovery by PET-scan of a previously undiagnosed lung cancer (n = 3) or parotid tumour (n = 1). Five patients with a positive PET scan required urgent surgery within two to 30 days. Among the 16 patients with negative PET-imaging of their aneurysm, only one had recent non-aortic surgery, none of them required urgent surgery, only two had a rapidly expanding AAA, and in only one patient, PET-imaging revealed an unknown lung cancer. Conclusion: these data suggest a possible association between increased 18-FDG uptake and AAA expansion and rupture.
Disciplines :
Surgery
Author, co-author :
SakalihasanN, Natzi ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire
Van Damme, Hendrik ; Université de Liège - ULiège > Département des sciences cliniques > Service de chirurgie cardio-vasculaire
Gomez, P.
Rigo, Pierre ; Université de Liège - ULiège > Département des sciences de la motricité > Pathologie générale et médecine nucléaire
Lapiere, C. M.
Nusgens, Betty ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Laboratoire de Biologie des Tissus Conjonctifs
Limet, Raymond ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Language :
English
Title :
Positron emission tomography (PET) evaluation of abdominal aortic aneurysm (AAA)
Publication date :
2002
Journal title :
European Journal of Vascular and Endovascular Surgery
Limet, R., Sakalihasan, N., Albert, A., Determination of the expansion rate and incidence of rupture of abdominal aortic aneurysms (1991) J Vasc Surg, 14, pp. 540-548
Mcmillan, W.D., Pearce, W.H., Inflammation and cytokine signaling in aneurysms (1997) Ann Vasc Surg, 11, pp. 540-545
Sakalihasan, N., Delvenne, P.H., Nusgens, B., Limet, R., Lapiere, C.H., Activated forms of MMP2 and MMP9 in abdominal aortic aneurysms (1996) J Vasc Surg, 24, pp. 127-133
Lindholt, J.S., Vammen, S., Fasting, H., Henneberg, E.W., Heickendorff, L., The plasma level of matrix metalloproteinase 9 may predict the natural history of small abdominal aortic aneurysms. A preliminary study (2000) Eur J Vasc Endovasc Surg, 20, pp. 281-285
Larson, S.M., Positron Emission Tomography in oncology and allied diseases (1999) "Cancer. Principles and Practice of Oncology", 2nd Ed., 3 (2), pp. 1-12. , Devita VT, Hellman S, Rosenberg SA (Eds), Philadelphia, JB Lippincott Publishing
Kubota, R., Yamada, S., Kubutu, K., Intramural distribution of fluorin-18-fluorodeoxyglucose in vivo: High accumulation in macrophages and granulation tissues studied by microautoradiographic comparison with FDG (1992) J Nucl Med, 33, pp. 1872-1980
Vallabhajosula, S., Machac, J., Knesaurek, K., Imaging atherosclerotic macrophage density by positron emission tomography using F-18-fluorodeoxyglycose (FDG) (1996) J Nucl Med, pp. 37-38
Swanson, K.J., Littooy, N.N., Hunt, T.E., Stoney, R.J., Laparotomy as a precipitating factor in the rupture of intraabdominal aneurysms (1980) Arch Surg, 115, pp. 229-265
Durham, S.J., Steed, D.L., Moosa, H.H., Makaroun, M.S., Webster, M.W., Probability of rupture of an abdominal aortic aneurysm after unrelated operative procedure: A prospective study (1991) J Vasc Surg, 13, pp. 248-252
Bernstein, L.R., Liotta, L.A., Molecular mediations of interactions with extracellular matrix components in metastasis and angiogenesis (1994) Curr Opin Oncol, 6, pp. 106-113
Newman, K.M., Jean-Claude, J., Li, H., Cellular localization of matrix metalloproteinases in the abdominal aortic aneurysm wall (1994) J Vasc Surg, 20, pp. 814-820
Thompson, R.W., Holmes, D.R., Mertens, R.A., Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms an elastolytic metalloproteinase expressed by aneurysm infiltrating macrophages (1995) J Clin Invest, 96, pp. 318-326
Shapiro, S.D., Campbell, E.J., Kobayashi, D.K., Welgus, H.G., Immune modulation of metalloproteinase production in human macrophages: Selective pretranslational suppression of interstitial collagenase and stromelysin biosynthesis by interferon-γ (1990) J Clin Invest, 86, pp. 1204-1210
Corcoran, M.L., Stetler-Stevenson, W.G., Brown, P.D., Wahl, L.M., Interleukin 4 inhibition of prostaglandin E2 synthesis blocks interstitial collagenase and 92-kDa type IV collagenase/gelatinase production by human monocytes (1992) J Biol Chem, 267, pp. 515-519
Dryer, T.D., Rudd, J.H.F., Warbuton, E.A., Imaging inflammation in carotid atherosclerotic plaque using FDG-PET (2001) Proceedings of the European Association of Nuclear Medicine Congress, , August, Naples (Italy): OS-388
