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27 May 2010
Article (Scientific journals)
Paget's Disease of Bone Treated with a Five Day Course of Oral Tiludronate
Reginster, Jean-Yves  ; Lecart, Marie-Paule  ; Deroisy, Rita  et al.
1993 • In Annals of the Rheumatic Diseases, 52 (1), p. 54-7
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Abstract :
[en] Chloro-4-phenyl thiomethylene bisphosphonate (tiludronate) is a new drug which can be used as an inhibitor of bone resorption. As it remains in bone for a long time, and as mineralisation defects have only been seen at doses much higher than those required to decrease osteoclastic activity, it could be given at high doses over a short period of time. Eighteen patients with Paget's disease of bone were randomly allocated to three therapeutic groups receiving respectively 600, 800, and 1200 mg/day tiludronate for five days. Serum alkaline phosphatase activity and the urinary hydroxyproline/creatinine ratio were quickly and drastically reduced in all three groups. A significant reduction of serum alkaline phosphatases and the hydroxyproline/creatinine ratio was still present six months after the five day therapeutic course, reflecting a sustained activity of tiludronate even after stopping treatment. Dose dependent short and long term reductions of bone turnover rate were observed. Biochemical assessment of haematological, renal, or hepatic tolerance did not show any toxicity of tiludronate. Fifty per cent of patients treated by a dose of 1200 mg/day reported gastrointestinal disturbances, however, making this dosage unsuitable for clinical practice.
Disciplines :
Rheumatology
Author, co-author :
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Lecart, Marie-Paule ;  Université de Liège - ULiège > Rhumatologie
Deroisy, Rita  ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
Ethgen, Dominique ;  Université de Liège - ULiège > Epidémiologie et santé publique
Zegels, Brigitte ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Franchimont, P.
Language :
English
Title :
Paget's Disease of Bone Treated with a Five Day Course of Oral Tiludronate
Publication date :
January 1993
Journal title :
Annals of the Rheumatic Diseases
ISSN :
0003-4967
eISSN :
1468-2060
Publisher :
BMJ Publishing Group, United Kingdom
Volume :
52
Issue :
1
Pages :
54-7
Peer reviewed :
Peer Reviewed verified by ORBi

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