Synthesis of biodegradable poly-epsilon-caprolactone microspheres by dispersion ring-opening polymerization in supercritical carbon dioxide

Grignard, Bruno; Stassin, Fabrice; Calberg, Cédric; Jérôme, Robert; Jérôme, Christine

doi:10.1021/bm800730m

Article (Scientific journals)

Synthesis of biodegradable poly-epsilon-caprolactone microspheres by dispersion ring-opening polymerization in supercritical carbon dioxide

Grignard, Bruno; Stassin, Fabrice; Calberg, Cédric et al.

2008 • In Biomacromolecules, 9 (11), p. 3141-3149

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/5739

DOI
10.1021/bm800730m

PubMed
18937397

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Keywords :

green technology; supercritical carbon dioxide; ring-opening polymerization (ROP); lactone

Abstract :

[en] A series of fluorinated diblock and triblock copolymers of poly(ε-caprolactone) and poly(heptadecafluorodecylacrylate) were prepared by combining ring-opening polymerization of ε-CL and atom transfer radical polymerization of the acrylate. These copolymers with well-controlled molecular weight and composition were characterized by 1H NMR spectroscopy and used as stabilizers for the dispersion ring-opening polymerization of ε-CL in supercritical carbon dioxide. The effect of composition and architecture of the polymeric stabilizers on the stabilization of PCL microspheres was investigated. Finally, purification of PCL was successfully implemented by reactive supercritical fluid extraction of the tin catalyst.

Research Center/Unit :

Center for Education and Research on Macromolecules (CERM)

Disciplines :

Chemistry
Materials science & engineering

Author, co-author :

Grignard, Bruno ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Stassin, Fabrice; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Calberg, Cédric ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Jérôme, Robert ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Jérôme, Christine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Language :

English

Title :

Synthesis of biodegradable poly-epsilon-caprolactone microspheres by dispersion ring-opening polymerization in supercritical carbon dioxide

Publication date :

10 November 2008

Journal title :

Biomacromolecules

ISSN :

1525-7797

eISSN :

1526-4602

Publisher :

American Chemical Society, Washington, United States - District of Columbia

Volume :

Issue :

Pages :

3141-3149

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://pubs.acs.org/doi/pdf/10.1021/bm800730m

Funders :

BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
The European Community for a fellowship of the “Polymerization and Polymer Modification in Supercritical Fluids: A Novel Way for Cleaner Manufacturing of Plastics (SUPERPOL)” project
The Région Wallonne for the financial support of the “Technologie et Matériaux Polymèes Innovants Préservants 1′Environnement (TECMAVER)” project

Available on ORBi :

since 05 February 2009

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