Smoothing the mosaic subclinical melanoderma by calcipotriol.

Administration, Topical; Calcitriol/administration & dosage/analogs & derivatives/therapeutic use; Dermatologic Agents/administration & dosage/therapeutic use; Double-Blind Method; Facial Dermatoses/diagnosis/drug therapy; Humans; Image Processing, Computer-Assisted; Male; Melanosis/diagnosis/drug therapy; Middle Aged; Statistics, Nonparametric; Treatment Outcome; Ultraviolet Rays/adverse effects

Abstract :

[en] BACKGROUND: The observation of photo-exposed skin under ultraviolet light reveals a mosaic pattern of varying intensity in epidermal melanization. Several patterns of mosaic subclinical melanoderma (MSM) have been described using a specially designed CCD camera and the ultraviolet light-enhanced visualization (ULEV) method. Vitamin D(3) and its analogues influence the biology of keratinocytes and melanocytes. OBJECTIVE: To assess the effect of calcipotriol on MSM. METHODS: This randomized split-face study was conducted in 27 men to compare the effect of once daily applications of 5% calcipotriol cream or a moisturizing cream on the heterogeneity of facial MSM. Computerized image analysis of video images was used at 1-month intervals before and during a 2-month treatment, as well as during a 3-month follow-up. RESULTS: At both sites, the average melanin content of the epidermis showed no significant change over time. However, the mottled appearance was smoothened at the calcipotriol site, whereas it was increased at the site receiving the moisturizer. CONCLUSION: The decreased heterogeneity in MSM after calcipotriol applications suggests a control of the epidermal melanocyte unit by the vitamin D(3) derivative.

Disciplines :

Dermatology

Author, co-author :

Pierard, Claudine ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Paquet, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Quatresooz, Pascale ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Language :

English

Title :

Smoothing the mosaic subclinical melanoderma by calcipotriol.

Publication date :

2007

Journal title :

Journal of the European Academy of Dermatology and Venereology

ISSN :

0926-9959

eISSN :

1468-3083

Publisher :

Blackwell Publishing, Oxford, United Kingdom

Volume :

Issue :

Pages :

657-61

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 05 February 2009

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