Article (Scientific journals)
Functional amphiphilic and biodegradable copolymers for intravenous vectorization
Van Butsele, Kathy; Jérôme, Robert; Jérôme, Christine
2007In Polymer, 48, p. 7431-7443
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Keywords :
biomaterial; nanomedicine; review
Abstract :
[en] This paper aims at reporting on the design of polymeric drug nanocarriers used in cancer therapy, with a special emphasis on the control of their biodistribution. First, the prominent role of poly(ethylene oxide) in the lifetime of nanocarriers circulating in the blood stream is highlighted, and the origin of a passive targeting based on a difference in the anatomy of tumors and normal tissues is discussed. The main body of the review is devoted to the targeting of nanocarriers towards tumors and the underlying concepts. As a rule, either the constitutive polymer is stimuli-responsive and the locus of drug release is where the stimulation occurs, or a ligand endowed with specific recognition is grafted onto the nanocarrier. Finally, the fate of the nanocarrier after drug delivery and the bioelimination of the polymer(s) involved are briefly considered.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Van Butsele, Kathy ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Robert ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Christine  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Functional amphiphilic and biodegradable copolymers for intravenous vectorization
Publication date :
13 December 2007
Journal title :
Polymer
ISSN :
0032-3861
eISSN :
1873-2291
Publisher :
Elsevier Science, Oxford, United Kingdom
Volume :
48
Pages :
7431-7443
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Commentary :
The authors acknowledge Polymer (Elsevier) for allowing them to archive this paper.
Available on ORBi :
since 03 February 2009

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