[en] A fast chemical synthesis of high specific activity [75Se]L-selenomethionine (10 Ci/mmol--370 GBq/mmol) is described with a view to 73Se labeling and PET studies. The overall radiochemical yield of the preparation is better than 80%. The purification method uses commercially available reverse phase HPLC columns and 9% NaCl as mobile phase. The final labeled compound is obtained in less than 3 h and the chemical, radiochemical and optical purities of the L-isomer are higher than 99.0%.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Chemistry
Author, co-author :
Plenevaux, Alain ; Université de Liège - ULiège > Centre de recherches du cyclotron
Cantineau, Robert
Guillaume, Marcel
Christiaens, Léon
Tihange, G.
Language :
English
Title :
Fast chemical synthesis of [75Se]L-selenomethionine.
Publication date :
1987
Journal title :
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
ISSN :
0883-2889
Publisher :
Pergamon Press, Oxford, United Kingdom
Volume :
38
Issue :
1
Pages :
59-61
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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