Reference : Fast chemical synthesis of [75Se]L-selenomethionine.
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Fast chemical synthesis of [75Se]L-selenomethionine.
Plenevaux, Alain mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Cantineau, Robert [> > > >]
Guillaume, Marcel [> > > >]
Christiaens, Léon [> > > >]
Tihange, G. [> > > >]
International Journal of Radiation Applications and Instrumentation. Part A : Applied Radiation and Isotopes
Pergamon Press
Yes (verified by ORBi)
United Kingdom
[en] Humans ; Radioisotopes/diagnostic use/isolation & purification ; Selenium/chemical synthesis/diagnostic use/isolation & purification ; Selenomethionine/chemical synthesis/diagnostic use ; Tomography, Emission-Computed
[en] A fast chemical synthesis of high specific activity [75Se]L-selenomethionine (10 Ci/mmol--370 GBq/mmol) is described with a view to 73Se labeling and PET studies. The overall radiochemical yield of the preparation is better than 80%. The purification method uses commercially available reverse phase HPLC columns and 9% NaCl as mobile phase. The final labeled compound is obtained in less than 3 h and the chemical, radiochemical and optical purities of the L-isomer are higher than 99.0%.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students

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