Analyse de l'expectoration induite dans l'asthme réfractaire

[en] Induction of sputum by inhalation of hypertonic or isotonic fluid makes possible the safe and noninvasive harvesting of airway cells from patients with asthma, regardless of disease severity. Analysis of sputum cells has helped to identify different phenotypes of refractory asthma and shown that such asthma can be eosinophilic, neutrophilic, or both. Elevated eosinophil levels in sputum indicate a risk of exacerbation if the corticosteroid dose is reduced in stabilized patients. Surveillance of eosinophilia levels as an indicator for corticosteroid adjustment in refractory asthma makes it possible to reduce the frequency of severe exacerbations.

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Louis, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie

Potmans, Vincent ; Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie

Language :

French

Title :

Analyse de l'expectoration induite dans l'asthme réfractaire

Alternative titles :

[en] Analysis of Induced Sputum in Refractory Asthma

Publication date :

January 2008

Journal title :

Presse Médicale

ISSN :

0755-4982

eISSN :

2213-0276

Publisher :

Masson, Moulineaux Cedex 9, France

Volume :

Issue :

1, Pt 2

Pages :

155-9

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.elsevier.com/wps/find/journaldescription.cws_home/709525/description#description

Available on ORBi :

since 02 February 2009

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Bibliography

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