Article (Scientific journals)
Fast F-18 FDG synthesis by alkaline hydrolysis on a low polarity solid phase supports
Lemaire, Christian; Damhaut, P.; Lauricella, Beniamino et al.
2002In Journal of Labelled Compounds and Radiopharmaceuticals, 45 (5), p. 435-447
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Keywords :
[18F]FDG; solid phase extraction; hydrolysis; ClDG; fluorine; [18F]FDM
Abstract :
[en] The synthesis of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) has been simplified by the use of a tC18 Sep Pak cartridge to effect purification and hydrolysis of the tetraacetylated [18F]fluoro-glucose compound ([18F]TAG). After radiolabelling, this derivative was trapped on a solid phase extraction (SPE) cartridge and the residual reaction solvent (CH3CN), reagents (K222, K2CO3,) and by-products removed by washing the support with water. After this cleaning step, the acetyl groups were cleaved on the same tC18 column using 2N sodium hydroxide. This fast reaction proceeded near quantitatively (>98%) at room temperature in less than 2 min. The [18F]FDG was then recovered with a small amount of water, neutralized with a slight excess of 2N hydrochloric acid, buffered for pH with a citrate solution and finally purified on a neutral alumina oxide and a second tC18 column. After filtration, the radiochemical yield of this [18F]FDG isotonic solution after more than 100 production runs was found to be very reliable and reproducible (70±6% decay corrected). The synthesis time was about 22 min. Quality controls showed that the radiochemical purity was higher than 98% and in any case no [18F]FDM was detected. Only traces of 2-chloro-2-deoxy-glucose (ClDG) were found in the final sample (64±9 g/ batch of 16 ml). [18F]FDG specific activity averaged between 1 and 20 Ci/µmol (EOS). No evaporation and use of ion retardation resin (AG11A8) are required. Moreover, this new approach is suitable for complete remote operation using available single use medical components. Copyright © 2002 John Wiley
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Chemistry
Author, co-author :
Lemaire, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Damhaut, P.
Lauricella, Beniamino ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Mosdzianowski, C.
Morelle, J. L.
Monclus, M.
Van Naemen, J.
Mulleneers, E.
Aerts, Joël ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Plenevaux, Alain  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Brihaye, C.
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Language :
English
Title :
Fast F-18 FDG synthesis by alkaline hydrolysis on a low polarity solid phase supports
Publication date :
2002
Journal title :
Journal of Labelled Compounds and Radiopharmaceuticals
ISSN :
0362-4803
eISSN :
1099-1344
Publisher :
John Wiley & Sons
Volume :
45
Issue :
5
Pages :
435-447
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 30 January 2009

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