Strategies for blood management in orthopaedic and trauma surgery.

Blood Loss, Surgical/prevention & control; Blood Transfusion/adverse effects/methods; Blood Transfusion, Autologous; Humans; Orthopedic Procedures/adverse effects; Orthopedics; Traumatology

Abstract :

[en] Several aspects of the management of an orthopaedic surgical patient are not directly related to the surgical technique but are nevertheless essential for a successful outcome. Blood management is one of these. This paper considers the various strategies available for the management of blood loss in patients undergoing orthopaedic and trauma surgery.

Disciplines :

Orthopedics, rehabilitation & sports medicine
Surgery

Author, co-author :

Lemaire, Roger ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)

Language :

English

Title :

Strategies for blood management in orthopaedic and trauma surgery.

Publication date :

2008

Journal title :

Journal of Bone and Joint Surgery, British Volume

ISSN :

0301-620X

Publisher :

British Editorial Society of Bone and Joint Surgery, United Kingdom

Volume :

Issue :

Pages :

1128-36

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 30 January 2009

Statistics

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146 (5 by ULiège)

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0 (0 by ULiège)

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Scopus citations^®

122

Scopus citations^®
without self-citations

122

OpenCitations

101

Bibliography

Callaghan JJ, Spitzer A. Blood management and patient specific transfusion options in total joint replacement surgery. Iowa Orthop J 2000;20:36-45.
Regan F, Taylor C. Blood transfusion medicine. BMJ 2002;325:143-7.
Keating EM, Meding JB. Perioperative blood management practices in elective orthopaedic surgery. J Am Acad Orthop Surg 2002;10:393-400.
Rosencher N, Kerkkamp HEM, Macheras G, et al. Blood management in elective knee and hip arthroplasty in Europe. Transfusion 2003;43:459-69.
Goodnough LT, Shander A. Blood management. Arch Pathol Lab Med 2007;131:695-701.
Carson JL, Willet LR. Is a hemoglobin of 10 g/dL required for surgery? Med Clin North Am 1993;77:335-47.
Carson JL, Duff A, Poses RM, et al. Effect of anaemia and cardiovascular disease on surgical mortality and morbidity. Lancet 1996;348:1055-60.
Spencer RK, Carson JA, Poses R, et al. Elective surgery without transfusion: influence of preoperative hemoglobin level and blood loss on mortality. Am J Surg 1990;159:320-4.
Nelson CL, Stewart JG. Primary and revision total hip replacement in patients who are Jehovah's witnesses. Clin Orthop 1999;369:251-61.
Fernandez MC, Gottlieb M, Menitove JE. Blood transfusion and postoperative infection in orthopedic patients. Transfusion 1992;32:318-22.
Edna TH, Bjerkeset T. Association between blood transfusion and infection in injured patients. J Trauma 1992;33:659-61.
Bierbaum BE, Callaghan JJ, Galante JO, et al. An analysis of blood management in patients having a total hip or knee arthroplasty. J Bone Joint Surg [Am] 1999;81-A:2-10.
Hill GE, Frawley WH, Griffith KE, Forestner JE, Minei JP. Allogeneic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis. J Trauma 2003;54:908-14.
Innerhofer P, Klingler A, Klimmer C, Fries D, Nussbaumer W. Risk for postoperative infection after transfusion of white blood cell-filtered allogeneic or autologous blood components in orthopedic patients undergoing primary arthroplasty. Transfusion 2005;45:103-10.
Vamvakas EC. Why have meta-analyses of randomized controlled trials of the association between non-white-blood-cell-reduced allogeneic blood transfusion and postoperative infection produced discordant results? Vix Sang 2007;93:196-207.
Vamvakas EC, Blajchman MA. Transfusion-related immunomodulation (TRIM): an update. Blood Rev 2007;21:327-48.
Landers DF, Hill GE, Wong KC, Fox IJ. Blood transfusion-induced immunomodulation. Anesth Analg 1996;82:187-204.
Flohé S, Kobbe P, Nast-Kolb D. Immunological reactions secondary to blood transfusion. Injury 2007;38:1405-8.
Pillonel J, Le Marrec N, Girault A, David D, Laperche S. Epidemiological surveillance of blood donors and residual risk of blood-borne infections in France, 2001 to 2003. Transfus Clin Biol 2005;12:239-46 (in French).
Soldan K, Davison K, Dow B. Estimates of the frequency of HBV, HCV, and HIV infectious donations entering the blood supply in the United Kingdom, 1996 to 2003. Euro Surveill 2005;10:17-19.
Hewitt PE, Llewelyn CA, Mackenzie J, Will RG. Creutzfeldt-Jakob disease and blood transfusion: results of the UK Transfusion Medicine Epidemiological Review study. Vox Sang 2006;91:221-30.
Blajchman MA. Incidence and significance of the bacterial contamination of blood components. Dev Biol (Basel) 2002;108:59-67.
Chiaroni J, Legrand D, Dettori I, Ferrera V. Analysis of ABO discrepancies occurring in 35 french hospitals. Transfusion 2004;44:860-4.
Newman JH, Bowers M, Murphy J. The clinical advantages of autologous transfusion: a randomized, controlled study after knee replacement. J Bone Joint Surg [Br] 1997;79-B:630-2.
Aderinto J, Brenkell IJ. Pre-operative predictors of the requirement for blood transfusion following total hip replacement. J Bone Joint Surg [Br] 2004;86-B:970-3.
Keating EM, Meding JB, Faris PM, Ritter MA. Predictors of transfusion risk in elective knee surgery. Clin Orthop 1998;357:50-9.
Salido JA, Marin LA, Gomez LA, Zorrilla P, Martinez C. Preoperative haemoglobin levels and the need for transfusion after prosthetic hip and knee surgery: analysis of predictive factors. J Bone Joint Surg [Am] 2002;84-A:216-20.
Walsh M, Preston C, Bong M, Patel V, Di Cesare PE. Relative risk factors for requirement of blood transfusion after total hip arthroplasty. J Arthroplasty 2007;22:1162-7.
Saleh E, McClelland DB, Hay A, Semple D, Walsh TS. Prevalence of anaemia before major joint arthroplasty and the potential impact of pre-operative investigation and correction on perioperative blood transfusions. Br J Anaesth 2007;99:801-8.
Feagan BG, Wong CJ, Lau CY, et al. Transfusion practice in elective orthopaedic surgery. Transfus Med 2001;11:87-95.
Nadler SB, Hidalgo JU, Bloch T. Prediction of blood volume in normal human adults. Surgery 1962;51:224-32.
Mercuriali F, Inghilleri G. Proposal of an algorithm to help the choice of the best transfusion strategy. Curr Med Res Opin 1996;13:465-78.
Sehat KR, Evans RL, Newmand JH. Hidden blood loss following hip and knee arthroplasty: correct management of blood loss should take hidden loss into account. J Bone Joint Surg [Br] 2004;86-B:561-5.
Lemaire R. Blood loss in orthopaedic and trauma surgery (in French). In: Duparc J, ed. Cahiers d'Enseignement de la SOFCOT, Elsevier, Paris 2003;82:247-61.
Foss NB, Kehlet H. Hidden blood loss after surgery for hip fracture. J Bone Joint Surg [Br] 2006;88-B:1053-9.
McManus KT, Velchik MG, Alavi A, Lotke PA. Non-invasive assessment of postoperative bleeding in TKA patients with Tc-99m RBCs. J Nuclear Med 1987;28:565.
Shapiro F, Zurakowski D, Sethna NF. Tranexamic acid diminishes intraoperative blood loss and transfusion in spinal fusions for Duchenne muscular dystrophy scoliosis. Spine 2007;32:2278-83.
Muñoz M, Breymann C, Garcia-Erce JA, et al. Efficacy and safety of intravenous iron therapy as an alternative/adjunct to allogeneic blood transfusion. Vox Sang 2008;94:172-83.
Auerbach M, Coyne D, Ballard H. Intravenous iron: from anathema to standard of care. Am J Hematol 2008;83:580-8.
Theusinger OM, Leyvraz PF, Schanz U, Seifert B, Spahn DR. Treatment of iron deficiency anemia in orthopedic surgery with intravenous iron: efficacy and limits: a prospective study. Anesthesiology 2007;107:923-7.
Laupacis A, Fergusson D. Erythropoietin to minimize perioperative blood transfusion: a systematic review of randomized trials. Transfus Med 1998;8:309-17.
Garcia-Erce JA, Cuenca J, Munoz M, et al. Perioperative stimulation of erythropoiesis with intravenous iron and erythropoietin reduces transfusion requirements in patients with hip fracture: a prospective observational study. Vox Sang 2005;88:235-43.
Faris PM, Ritter MA. Epoetin alfa: a bloodless approach for the treatment of perioperative anemia. Clin Orthop 1998;357:60-7.
Johnson OC, Chebli C, Aboulafia AJ. Advances in therapeutics and diagnostics: epoetin alfa. J Am Acad Orthop Surg 2003;11:77-80.
Earnshaw P. Blood conservation in orthopaedic surgery: the role of epoetin alfa. Int Orthop 2001;25:273-8.
Robinson CM, Christie J, Malcolm-Smith N. Nonsteroidal antiinflammatory drugs, perioperative blood loss, and transfusion requirements in elective hip arthroplasty. J Arthroplasty 1993;8:607-10.
Slappendel R, Weber EW, Benraad B, Dirksen R, Bugter ML. Does ibuprofen increase perioperative blood loss during hip arthroplasty? Eur J Anaesthesiol 2002;19:829-31.
Bong MR, Patel V, Chang E, et al. Risks associated with blood transfusion after total knee arthroplasty. J Arthroplasty 2004;19:281-7.
Haentjens P, Lemaire R. A pragmatic approach to prophylaxis of thromboembolic complications in orthopaedic surgery. In: Duparc J, ed. Surgical techniques in orthopaedics and traumatology. Elsevier, 2001:55-010-D-30.
Locher S, Kühne R, Lottenbach M, Bamert P. Blood loss in total hip prosthesis implantation: lateral versus supine position. Z Orthop Ihre Grenzgeb 1999;137:148-52 (in German).
Pace A, Yousef A. The effect of patient position on blood loss in primary cemented total hip arthroplasty. Arch Orthop Trauma Surg 2008 (in press).
Ong SM, Taylor GJ. Can knee position save blood following total knee replacement? Knee 2003;10:81-5.
Juelsgaard P, Larsen UT, Søorensen JV, Madsen F, Søballe K. Hypotensive epidural anesthesia in total knee replacement without tourniquet: reduced blood loss and transfusion. Reg Anesth Pain Med 2001;26:105-10.
Paul JE, Ling E, Lalonde C, Thabane L. Deliberate hypotension in orthopedic surgery reduces blood loss and transfusion requirements: a meta-analysis of randomized controlled trials. Can J Anaesth 2007;54:799-810.
Wang GJ, Hungerford DS, Savory CG, et al. Use of fibrin sealant to reduce bloody drainage and hemoglobin loss after total knee arthroplasty: a brief note on a randomized prospective trial. J Bone Joint Surg [Am] 2001;83-A:1503-5.
Carless PA, Henry DA, Anthony DM. Fibrin sealant use for minimising peri-operative allogeneic blood transfusion. Cochrane Database Syst Rev 2003;2:CD004171.
Isarangkura P, Chiewsilp P, Chuansumrit A, et al. Low cost locally prepared fibrin glue for clinical applications: reported of 145 cases. Commitee of Bangkok International Hemophilia Training Center. J Med Assoc Thai 1999;82(Suppl 1):49-56.
Everts PA, Devilee RJ, Brown Mahoney C, et al. Platelet gel and fibrin sealant reduce allogeneic blood transfusions in total knee arthroplasty. Acta Anaesthesiol Scand 2006;50:593-9.
De Bonis M, Cavaliere F, Alessandrini F, et al. Topical use of tranexamic acid in coronary artery bypass operations: a double-blind, prospective, randomized, placebo-controlled study. J Thorac Cardiovasc Surg 2000;119:575-80.
Krohn CD, Sørensen R, Lange JE, et al. Tranexamic acid given into the wound reduces postoperative blood loss by half in major orthopaedic surgery. Eur J Surg Suppl 2003;588:57-61.
Flordal PA, Ljungström KG, Ekman B, Neander G. Effects of desmopressin on blood loss in hip arthroplasty: controlled study in 50 patients. Acta Orthop Scand 1992;63:381-5.
Schött U, Sollén C, Axelsson K, Rugarn O, Allvin I. Desmopressin acetate does not reduce blood loss during total hip replacement in patients receiving dextran. Acta Anaesthesiol Scand 1995;39:592-8.
Karnezis TA, Stulberg SD, Wixson RL, Reilly P. The hemostatic effects of desmopressin on patients who had total joint arthroplasty: a double-blind randomized trial. J Bone Joint Surg [Am] 1994;76-A:1545-50.
Carless PA, Henry DA, Moxey AJ, et al. Desmopressin for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2004;1:CD001884.
Janssens M, Joris J, David JL, Lemaire R, Lamy M. High-dose aprotinin reduces blood loss in patients undergoing total hip replacement surgery. Anesthesiology 1994;80:23-9.
Kinzel V, Shakespear D, Derbyshire D. The effect of aprotinin on blood loss in bilateral total knee arthroplasty. Knee 2005;12:107-11.
Lentschener C, Cottin P, Bouaziz H, et al. Reduction of blood loss and transfusion requirement by aprotinin in posterior lumbar spine fusion. Anesth Analg 1999;89:590-7.
Okubadejo GO, Bridwell KH, Lenke LG, et al. Aprotinin may decrease blood loss in complex adult spinal deformity surgery, but it may also increase the risk of acute renal failure. Spine 2007;32:2265-71.
Husted H, Blond L, Sonne-Holm S, et al. Tranexamic acid reduces blood loss and blood transfusions in primary total hip arthroplasty: a prospective randomized double blind study in 40 patients. Acta Orthop Scand 2003;74:665-9.
Johansson T, Pettersson LG, Lisander B. Tranexamic acid in total hip arthroplasty saves blood and money: a randomized, double-blind study in 100 patients. Acta Orthop 2005;76:314-19.
Claeys MA, Vermeersch N, Haentjens P. Reduction of blood loss with tranexamic acid in primary total hip replacement surgery. Acta Chir Belg 2007;107:397-401.
Benoni G, Fredin H. Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients. J Bone Joint Surg [Br] 1996;78-B:434-40.
Cid J, Lozano M. Tranexamic acid reduces allogeneic red cell transfusions in patients undergoing total knee arthroplasty: results of a meta-analysis of randomized controlled trial. Transfusion 2005;45:1302-7.
Camarasa MA, Ollé G, Serra-Prat M, et al. Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. Br J Anaesth 2006;96:576-82.
Sethna NF, Zurakowski D, Brustowicz RM, et al. Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery. Anesthesiology 2005;102:727-32.
Neilipovitz DT. Tranexamic acid for major spinal surgery. Eur Spine J 2004;13(Suppl 1):62-5.
Ho KM, Ismail H. Use of intravenous tranexamic acid to reduce allogeneic blood transfusion in total hip and knee arthroplasty: a meta-analysis. Anaesth Intensive Care 2003;31:529-37.
Henry DA, Carless PA, Moxey AJ, et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2007;4:CD001886.
Molloy DO, Archbold HA, Ogonda L, et al. Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trial. J Bone Joint Surg [Br] 2007;89-B:306-9.
Zohar E, Ellis M, Ifrach N, et al. The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacement. Anesth Analg 2004;99:1679-83.
Rizoli SB, Nascimento B Jr, Osman F, et al. Recombinant activated coagulation factor VII and bleeding trauma patients. J Trauma 2006;61:1419-25.
Chandrateya A, Giannikas K, Livesley P. To drain or not drain: literature versus practice. J R Coll Surg Edinb 1998;43:404-6.
Parker MJ, Livingstone V, Clifton R, McKee A. Closed suction surgical wound drainage after orthopaedic surgery. Cochrane Database Syste Rev 2007;3:CD001825.
Mengal B, Aebi J, Rodriguez A, Lemaire R. A prospective randomized study of wound drainage versus non-drainage in primary total hip or knee arthroplasty. Rev Chir Orthop Reparatrice Appar Mot 2001;87:29-39 (in French).
Johansson T, Enquist M, Pettersson LG, Lisander B. Blood loss after total hip replacement: a prospective randomized study betwen wound compression and drainage. J Arthroplasty 2005;20:967-71.
Clifton R, Norrish AR, Howell FR. Reducing blood loss after total hip arthroplasty: a prospective randomised controlled trial to evaluate the efficacy of temporarily clamping drains. Hip International 2005;15:108-11.
Brueggemann PM, Tucker JK, Wilson P. Intermittent clamping of suction drains in total hip replacement reduces postoperative blood loss: a randomized, controlled trial. J Arthroplasty 1999;14:470-2.
Kiely N, Hockings M, Gambhir A. Does temporary clamping of drains following knee arthroplasty reduce blood loss?: a randomised controlled trial. Knee 2001;8:325-7.
Roy N, Smith M, Anwar M, Elsworth C. Delayed release of drain in total knee replacement reduces blood loss: a prospective randomised study. Acta Orthop Belg 2006;72:34-8.
Shen PC, Jou IM, Lin YT, et al. Comparison between 4-hour clamping drainage and nonclamping drainage after total knee arthroplasty. J Arthroplasty 2005;20:909-13.
Wittmann FW, Ring PA. Blood loss associated with Ring uncemented total knee replacement: comparison between continuous and intermittent suction drainage. R Soc Med 1984;77:556-8.
Raleigh E, Hing CB, Hanusiewicz AS, Fletcher SA, Price R. Drain clamping in knee arthroplasty: a randomized controlled trial. ANZ J Surg 2007;77:333-5.
Prasad N, Padmanabhan V, Mullajo A. Comparison between two methods of drain clamping after total knee arthroplasty. Arch Orthop Trauma Surg 2005;125:381-4.
Ryu J, Sakamoto A, Honda T, Saito S. The postoperative drain-clamping method for hemostasis in total knee arthroplasty: reducing postoperative bleeding in total knee arthroplasty. Bull Hosp Jt Dis 1997;56:251-4.
Tsumara N, Yoshiya S, Chin T, et al. A prospective comparison of clamping the drain or post-operative salvage of blood in reducing blood loss after total knee arthroplasty. J Bone Joint Surg [Br] 2006;88-B:49-53.
Yamada K, Imaizumi T, Uemura M, Takada N, Kim Y. Comparison between 1-hour and 24-hour drain clamping using diluted epinephrine solution after total knee arthroplasty. J Arthroplasty 2001;16:458-62.
Varley GW, Milner S, Turner GM, Crisp AJ, Szypryt EP. Ultrasound assessment of the efficacy of wound drains. J R Coll Surg Edinb 1994;39:97-9.
Widman J, Jacobsson H, Larsson SA, Isacson J. No effect of drains on the postoperative hematoma volume in hip replacement surgery: a randomized study using scintigraphy. Acta Orthop Scand 2002;73:625-9.
Drinkwater CJ, Neil MJ. Optimal timing of wound drain removal following total joint arthroplasty. J Arthroplasty 1995;10:185-9.
Tetro AM, Rudan JF. The effects of a pneumatic tourniquet on blood loss in total knee arthroplasty. Can J Surg 2001;44:33-8.
Klenerman L. Is a tourniquet really necessary for knee replacement? J Bone Joint Surg [Br] 1995;77-B:174-5.
Aglietti P, Baldini A, Vena LM, et al. Effect of tourniquet on activation of coagulation in total knee replacement. Clin Orthop 2000;371:169-77.
Hersekli MA, Akpinar S, Ozkoc G, et al. The timing of tourniquet release and its influence on blood loss after total knee arthroplasty. Int Orthop 2004;28:138-41.
Lotke PA, Faralli VJ. Orenstein EM, Ecker ML. Blood loss after total knee replacement: effects of tourniquet release and continuous passive motion. J Bone Joint Surg [Am] 1991;73-A:1037-40.
Mielke LL, Entholzner EK, Kling M, et al. Preoperative acute hypervolemic hemodilution with hydroxyethylstarch: an alternative to acute normovolemic hemodilution? Anesth Analg 1997;84:26-30.
Kumar R, Chakraborty I, Sehgal R. A prospective randomized study comparing two techniques of perioperative blood conservation: isovolemic hemodilution and hypervolemic hemodilution. Anesth Analg 2002;95:1154-61.
Bryson GL, Laupacis A, Wells GA. Does acute normovolemic hemodilution reduce perioperative allogeneic transfusion?: a meta-analysis. Anesth Analg 1998;86:9-15.
Zohar E, Fredman B, Ellis M, et al. A comparative study of the postoperative allogeneic blood-sparing effect of tranexamic acid versus acute normovolemic hemodilution after total knee replacement. Anesth Analg 1999;89:1382-7.
Henry DA, Carless PA, Moxey AJ, et al. Pre-operative autologous donation for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2002;2:CD003602.
Brecher ME, Goodnough LT. The rise and fall of preoperative autologous blood donation. Transfusion 2002;42:1618-22.
Popovsky MA, Whitaker B, Arnold NL. Severe outcomes of allogeneic and autologous blood donation: frequency and characterization. Transfusion 1995;35:734-7.
Mercuriali F, Inghilleri G. Proposal of an algorithm to help the choice of the best transfusion strategy? Curr Med Res Opin 1996;13:465-78.
Keating EM, Callaghan JJ, Ranawat AS, Bhirangi K, Ranawat CS. A randomized, parallel-group, open-label trial of recombinant human erythropoietin vs preoperative autologous donation in primary total joint arthroplasty: effect on postoperative vs vigor and handgrip strength. J Arthroplasty 2007;22:325-33.
Stowell CP, Chandler H, Jove M, Guilfoyle M, Wacholtz M. An open-label, randomized study to compare the safety and efficacy of perioperative epoetin alfa with preoperative autologous blood donation in total joint arthroplasty. Orthopedics 1999;22(Suppl 1):105-12.
Gargaro JM, Walls CE. Efficacy of intraoperative autotransfusion in primary total hip arthroplasty. J Arthroplasty 1991;6:157-61.
Schmied H, Schiferer A, Sessler DI, Meznik C. The effects of red-cell scavenging, hemodilution, and active warming on allogenic blood requirements in patients undergoing hip or knee arthroplasty. Anesth Analg 1998;86:387-91.
Slagis SV, Benjamin JB, Volz RG, Giordano GF. Postoperative blood salvage in total hip and knee arthroplasty: a randomised controlled trial. J Bone Joint Surg [Br] 1991;73-B:591-4.
Carless PA, Henry DA, Moxey AJ, et al. Cell salvage for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2006;4:CD001888.
Davies L, Brown TJ, Haynes S, et al. Cost-effectiveness of cell salvage and alternative methods of minimising perioperative allogeneic blood transfusion: a systematic review and economic model. Health Technol Assess 2006;10:1-210.
Moonen AFCM, Pilot P, Meijers WGH, et al. Filters in autologous blood retransfusion systems affect the amount of blood cells retransfused in total knee arthroplasty: a pilot study. Acta Orthop Belg 2008;74:209-15.
Andersson I, Tylman M, Bengtson JP, Bengtsson A. Complement split products and pro-inflammatory cytokines in salvaged blood after hip and knee arthroplasty. Canad J Anesthes 2001;48:251-5.
Muñoz M, Cobos A, Campos A, et al. Impact of postoperative shed blood transfusion, with or without leucocyte reduction, on acute-phase response to surgery for total knee replacement. Acta Anaesthesiol Scand 2005;49:1182-90.
Pitsaer E. Transfusion of recuperated blood in total knee arthroplasty. Rev Chir Orthop Reparatrice Appar Mot 2002;88:777-89 (in French).
Xenakis TA, Malizos KN, Dailiani Z, et al. Blood salvage after total hip and total knee arthroplasty. Acta Orthop Scand Suppl 1997;275:135-8.
Keating EM, Ritter MA. Transfusion options in total joint arthroplasty. J Arthroplasty 2002;17:125-8.
Newman JH, Bowers M, Murphy J. The clinical advantages of autologous transfusion: a randomised, controlled study after knee replacement. J Bone Joint Surg [Br] 1997;79-B:630-2.
Sturdee SW, Beard DJ, Nandhara G, Sonanis SV. Decreasing the blood transfusion rate in elective hip replacement surgery using an autologous drainage system. Ann R Coll Surg Engl 2007;89:136-9.
Spahn DR, Kocian R. Artificial O2 carriers: status in 2005. Curr Pharm Des 2005;11:4099-114.
Smani Y, Labrude P, Vigneron C, Faivre B. Hemoglobin-based oxygen carrier and trials to substitute red blood cells. Transfus Clin Biol 2007;14:464-73 (in French).
Gould SA, Moore EE, Hoyt DB, et al. The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailable. J Am Coll Surg 2002;195:445-52.
Levy JH, Goodnough LT, Greilich PE, et al. Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial. J Thorac Cardiovasc Surg 2002;12:35-42.
Jones AP, Harrison M, Hui A. Comparison of autologous transfusion drains versus no drain in total knee arthroplasty. Acta Orthop Belg 2007;73:377-85.
Majkowski RS, Currie IC, Newman JH. Postoperative collection and reinfusion of autologous blood in total knee arthroplasty. Ann R Coll Surg Engl 1991;73:381-4.
Kalairajah Y, Simpson D, Cossey AJ, Verrall GM, Spriggins AJ. Blood loss after total knee replacement: effects of computer-assisted surgery. J Bone Joint Surg [Br] 2005;87-B:1480-2.
Woolson ST. In the absence of evidence: why bother?: a literature review of minimally invasive total hip replacement surgery. Instr Course Lect 2006;55:189-93.