Solid phase extraction : An alternative to the use of rotary evaporators for solvent removal in the rapid formulation of PET radiopharmaceuticals

Lemaire, Christian; Plenevaux, Alain; Aerts, Joël; Del Fiore, Guy; Brihaye, C.; Le Bars, Didier; Comar, Dominique; Luxen, André

doi:10.1002/(SICI)1099-1344(199901)42:1<63::AID-JLCR167>3.0.CO;2-R

Article (Scientific journals)

Solid phase extraction : An alternative to the use of rotary evaporators for solvent removal in the rapid formulation of PET radiopharmaceuticals

Lemaire, Christian; Plenevaux, Alain; Aerts, Joël et al.

1999 • In Journal of Labelled Compounds and Radiopharmaceuticals, 42 (1), p. 63-75

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https://hdl.handle.net/2268/5084

DOI
10.1002/(SICI)1099-1344(199901)42:1<63::AID-JLCR167>3.0.CO;2-R

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Keywords :

PET; radiopharmaceutical; formulation; solid-phase-extraction; automation

Abstract :

[en] Solid phase extraction (SPE) was used for the formulation of several radiopharmaceuticals. The method involves dilution of the previously purified HPLC compound with water, trapping of the activity on an SPE bed, washing off the support, elution of the radiopharmaceutical with a small volume of ethanol (<1 mL) and dilution with sterile isotonic saline solution. Recovery of the radiopharmaceuticals was always higher than 97%. Two different methods of automation were developed for the formulation of [11C] and [18F]radiopharmaceuticals. In all cases, organic solvent levels in the injectable solution were below the recommended limits. This fast (3-6 min.) and easy to automate process can be considered as an alternative to the conventional methods (rotary evaporators). Copyright © 1999 John Wiley

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Chemistry

Author, co-author :

Lemaire, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron

Plenevaux, Alain ; Université de Liège - ULiège > Centre de recherches du cyclotron

Aerts, Joël ; Université de Liège - ULiège > Centre de recherches du cyclotron

Del Fiore, Guy

Brihaye, C.

Le Bars, Didier; Centre d'Exploration et de Recherche Médicales par Émission de Positons - CERMEP (Lyon)

Comar, Dominique

Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron

Language :

English

Title :

Solid phase extraction : An alternative to the use of rotary evaporators for solvent removal in the rapid formulation of PET radiopharmaceuticals

Publication date :

1999

Journal title :

Journal of Labelled Compounds and Radiopharmaceuticals

ISSN :

0362-4803

eISSN :

1099-1344

Publisher :

John Wiley & Sons

Volume :

Issue :

Pages :

63-75

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 29 January 2009

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Bibliography

Mazière B., Coenen H.H., Halldin C., Nagren K. and Pike V.W. - Nucl. Med. Biol. 12: 497 (1992)
Meyer G.J., Coenen H.H., Waters S.L., Langström B., Cantineau R., Strijckmans K., Vaalburg W., Halldin C., Crouzel C., Mazière B. and Luxen A. - Quality assurance and quality control of short-lived radiopharmaceuticals for PET. G. Stocklin and V. W. Pike, eds. Radiopharmaceuticals for positron emission tomography. The Netherland, Kluwer Academic Publishers, 91 (1993)
Pike V.W., Halldin C., Crouzel C., Barré L., Nutt D.J., Osman S., Shah F., Turton D.R., and Waters S.L. - Nucl. Med. Biol. 20: 503 (1993)
Lemaire C., Cantineau R., Guillaume M., Plenevaux A. and Christiaens L. - J Nucl Med. 32: 2266 (1991)
Pascali C., Luthra S.K., Pike V.W., Price G.W., Ahier R.G., Hume S.P., Myers R., Manjil L. and Cremer J.E. - Appl. Radiat. Isot. 41; 477 (1990)
Curran D.P. -Angew. Chem. Int. Ed., 37: 1174 (1998)
Chakraborty P.K., Mangner T.J., Chugani D.C., Muzik O. and Chugani H.T. - Nucl. Med. Biol. 23: 1005 (1996)
Livni E., Fischman A.J., Ray S., Sinclair I., Elmaleh D.R., Alpert N.M., Weiss S., Correia J.A., Webb D., Dahl R., Robeson W., Margouleff D., Liss R., Strauss H.W. and Rubin R.H.-Nucl. Med. Biol. 12: 191 (1992)
Lemaire C., Damhaut Ph., Lauricella B., Morelle J-L., Monclus M., Van Naemen J., Mulleneers E., Aerts J., Plenevaux A., Brihaye C. and Luxen A. - J. Labelled Compd. Radiopharm. 40: 256 (1997)
Suzuki K., Inoue O., Hashimoto K., Yamazaki T., Kuchiki M. and Tamate K. - Appl. Radiat. Isot. 36: 971 (1985)
Halldin C., Stone-Elander S., Thorell J.O., Persson A. and Sedvall G. - Appl. Radiat. Isot. 39: 993 (1988)
Mazière M., Hantraye P., Prenant C., Sastre J. and Comar D. - Appl. Radiat. Isot. 35: 973 (1984)
Sadzot B., Lemaire C., Maquet P., Salmon E., Plenevaux A., Degueldre C., Hermanne J-P., Guillaume M., Cantineau R., Comar D. and Franck G. - J. Cereb. Blood Flow. Metab. 15: 787 (1995)
Lewis S.J. Handbook of Pharmaceutical Excipients. Second edition, Wade A. and Weller P.J. editors. The Pharmaceutical Press London. Alcohol 7-9 (1994)
Freund G., Ballinger W. E. J. Alcohol, 5: 275 (1988)
Litton J. E., Neiman J., Pauli S., Farde L., Hindmarsh T., Halldin C., Sedvall G. -Psychiatry Res, 50: 1 (1993), 1
Gilman S., Koeppe R. A., Adams K., Johnson-Greene D., Junck L., Kluin K. J., Brunberg J., Martorello S., Lohman M. -Ann Neurol, 40 : 163 (1996)
Farde L., Pauli S., Litton J. E., Halldin C., Neiman J., Sedvall G. EXS, 71 : 143 (1994)
Pauli S., Liljequist S., Farde L., Swhan C. G., Halldin C., Litton J. E., Sedvall G. -Psychopharmacology, 107 : 180 (1992)
Le Bars D., Lemaire C., Ginovart N., Plenevaux A., Aerts J., Hassoun W., Leviel V., Mekhsian P., Weissmann D., Pujol J-F., Luxen A. and Comar D.-Nucl. Med. Biol. 25:343 (1998)
Gachon M. - S.T.P. Pharma Pratiques. 1: 531 (1991)
David N.A. - Ann. Rev. Pharmacol. 12: 353 (1972)
2-Fluoro-2-desoxy-D-glucose (18F), (solution injectable de). Pharmeuropa. 8: 525 (1996)
European Pharmacopoeia Commission. - A proposal for a guideline for residual solvent levels in drug substances ans excipients used for the preparation of medicinal products from the working party "Residual solvents (toxicology)" (1994).