Article (Scientific journals)
Solid phase extraction : An alternative to the use of rotary evaporators for solvent removal in the rapid formulation of PET radiopharmaceuticals
Lemaire, Christian; Plenevaux, Alain; Aerts, Joël et al.
1999In Journal of Labelled Compounds and Radiopharmaceuticals, 42 (1), p. 63-75
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Keywords :
PET; radiopharmaceutical; formulation; solid-phase-extraction; automation
Abstract :
[en] Solid phase extraction (SPE) was used for the formulation of several radiopharmaceuticals. The method involves dilution of the previously purified HPLC compound with water, trapping of the activity on an SPE bed, washing off the support, elution of the radiopharmaceutical with a small volume of ethanol (<1 mL) and dilution with sterile isotonic saline solution. Recovery of the radiopharmaceuticals was always higher than 97%. Two different methods of automation were developed for the formulation of [11C] and [18F]radiopharmaceuticals. In all cases, organic solvent levels in the injectable solution were below the recommended limits. This fast (3-6 min.) and easy to automate process can be considered as an alternative to the conventional methods (rotary evaporators). Copyright © 1999 John Wiley
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Chemistry
Author, co-author :
Lemaire, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Plenevaux, Alain  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Aerts, Joël ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Del Fiore, Guy
Brihaye, C.
Le Bars, Didier;  Centre d'Exploration et de Recherche Médicales par Émission de Positons - CERMEP (Lyon)
Comar, Dominique
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Language :
English
Title :
Solid phase extraction : An alternative to the use of rotary evaporators for solvent removal in the rapid formulation of PET radiopharmaceuticals
Publication date :
1999
Journal title :
Journal of Labelled Compounds and Radiopharmaceuticals
ISSN :
0362-4803
eISSN :
1099-1344
Publisher :
John Wiley & Sons
Volume :
42
Issue :
1
Pages :
63-75
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 29 January 2009

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