[en] Background/Aims: The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer's disease (AD). Methods: Cross-sectional data of 2,354 patients with AD from 12 centres from the European Alzheimer's Disease Consortium were collected. Principal component analysis was used for factor analysis. Results: The results showed the presence of 4 neuropsychiatric subsyndromes: hyperactivity, psychosis, affective symptoms and apathy. The subsyndrome apathy was the most common, occurring in almost 65% of the patients. Conclusion: This large study has provided additional robust evidence for the existence of neuropsychiatric subsyndromes in AD. Copyright (c) 2007 S. Karger AG, Basel.
Disciplines :
Sociology & social sciences Geriatrics Neurology
Author, co-author :
Aalten, Pauline; Maastricht University Hospital > Alzheimer Centre Limburg > Department of Psychiatry and Neuropsychology
Verhey, Frans R. J.; Maastricht University Hospital > Alzheimer Centre Limburg > Department of Psychiatry and Neuropsychology
Boziki, Marina
Bullock, Roger
Byrne, Eleanor Jane
Camus, Vincent
Caputo, Miriam
Collins, Debby
De Deyn, Peter Paul
Elina, Kazi
Frisoni, Giovanni
Girtler, Nicola
Holmes, Clive
Hurt, Catherine
Marriott, Anna
Mecocci, Patrizia
Nobili, Flavio
Ousset, Pierre Jean
Reynish, Emma
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
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