Article (Scientific journals)
Nf-Kappab Activation in Response to Toxical and Therapeutical Agents: Role in Inflammation and Cancer Treatment
Bours, Vincent; Bonizzi, Giuseppina; Bentires-Alj, Mohamed et al.
2000In Toxicology, 153 (1-3), p. 27-38
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Keywords :
Transcription factors; NF-kB; Inflammation; cancer
Abstract :
[en] The NF-kappaB transcription factor is ubiquitously expressed and controls the expression of a large number of genes. Experimental data clearly indicate that NF-kappaB is a major regulator of the inflammatory reaction by controlling the expression of pro-inflammatory molecules in response to cytokines, oxidative stress and infectious agents. We demonstrated that NF-kappaB activation by IL-1beta follows three distinct cell-specific pathways. Moreover, our studies indicated that in one model of inflammatory diseases, horse recurrent airway obstruction (RAO), the extent of NF-kappaB basal activity correlates with pulmonary dysfunction. Another role of NF-kappaB activity protects cancer cells against apoptosis and could participate in the resistance to cancer treatment. However, we did not observe any increased cytotoxicity after treatment with anticancer drugs or TNF-alpha of cells expressing a NF-kappaB inhibitor. Therefore, we can conclude that the inhibition of apoptosis by NF-kappaB is likely to be cell type and stimulus-dependent. Further studies are required to determine whether NF-kappaB could be a target for anticancer treatments.
Disciplines :
Genetics & genetic processes
Author, co-author :
Bours, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique générale et humaine
Bonizzi, Giuseppina
Bentires-Alj, Mohamed
Bureau, Fabrice ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Biochimie et biologie moléculaire
Piette, Jacques ;  Université de Liège - ULiège > Département des sciences de la vie > Virologie - Immunologie
Lekeux, Pierre ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
Merville, Marie-Paule ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Nf-Kappab Activation in Response to Toxical and Therapeutical Agents: Role in Inflammation and Cancer Treatment
Publication date :
16 November 2000
Journal title :
Toxicology
ISSN :
0300-483X
eISSN :
1879-3185
Publisher :
Elsevier, Netherlands
Volume :
153
Issue :
1-3
Pages :
27-38
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 January 2009

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