Role of protein tyrosine phosphatases in T cell activation.

Animals; Antigens, CD45/physiology; Autoimmune Diseases/metabolism; Humans; Protein Tyrosine Phosphatases/physiology; Signal Transduction/physiology; T-Lymphocytes/enzymology

Abstract :

[en] The last decade has seen an exponentially increasing interest in the molecular mechanisms of signal transduction. In T cells, much of the focus has been on protein tyrosine kinase (PTK)-mediated signaling from the T cell receptor (TCR) and cytokine receptors, while the study of protein tyrosine phosphatases (PTPases) has lagged behind. However, recent discoveries have revealed that several PTPases play important roles in many different aspects of T cell physiology. We predict that the phosphatases will become a 'hot topic' in the field within the next few years. This review summarizes the current understanding of the regulation and biology of PTPases in T lymphocyte activation.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Mustelin, Tomas; Burnham Institute > Cancer Research Center

Rahmouni, Souad ; Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Transplantation

Bottini, Nunzio; Burnham Institute > Cancer Research Center

Alonso, Andres; Burnham Institute > Cancer Research Center

Language :

English

Title :

Role of protein tyrosine phosphatases in T cell activation.

Publication date :

2003

Journal title :

Immunological Reviews

ISSN :

0105-2896

eISSN :

1600-065X

Publisher :

Munksgaard International Publishers, Copenhagen, Denmark

Volume :

191

Pages :

139-47

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 January 2009

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73 (9 by ULiège)

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2 (2 by ULiège)

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Bibliography

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