Article (Scientific journals)
Les glioblastomes, un exemple de recherche translationnelle?
Kroonen, Jérôme; Nguyen-Khac, Minh-Tuan; Deprez, Manuel et al.
2008In Revue Médicale de Liège, 63 (5-6), p. 251-6
Peer reviewed
 

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Keywords :
Biomedical Research; Brain Neoplasms/pathology; Glioblastoma/pathology; Humans; Neoplasm Recurrence, Local/pathology; Neoplastic Stem Cells
Abstract :
[en] Among patients which develop glioblastoma multiform (GBM), recurrence is the rule despite continuous progress in surgery, radiotherapy and chemotherapy. In the adult, GBM is the most frequent and most aggressive tumour of the Central Nervous System. A better understanding of the mechanisms by which these tumours relapse could promote the use of preventive therapy and could increase patients' survival. GBM stem cells have been recently described and it was demonstrated that they are specifically implied in the experimental tumorigenesis. It is thus very attractive to speculate on a possible relationship between these GBM stem cells and the neural stem cells which are persisting in the neurogenic zones of the adult brain. In this review, we formulate and discuss the hypothesis by which, in a patient with GBM, malignant stem cells might be present in the neurogenic zones, away from the tumour mass. This hypothesis could explain the tumour relapse observed after the first treatments.
Disciplines :
Neurology
Author, co-author :
Kroonen, Jérôme ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Nguyen-Khac, Minh-Tuan ;  Université de Liège - ULiège > Département des sciences cliniques > Neurochirurgie
Deprez, Manuel ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Rogister, Bernard  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Robe, Pierre ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique générale et humaine - Département des sciences biomédicales et précliniques
Language :
French
Title :
Les glioblastomes, un exemple de recherche translationnelle?
Alternative titles :
[en] Glioblastoma, an example of translational research?
Publication date :
2008
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
63
Issue :
5-6
Pages :
251-6
Peer reviewed :
Peer reviewed
Available on ORBi :
since 26 January 2009

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