Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin beta is the true human homologue of rat thymosin beta 15

Dhaese, S.; Jonckheere, V.; Goethals, M.; Waltregny, David; Vandekerckhove, J.; Ampe, C.; Van Troys, M.

doi:10.1016/j.febslet.2007.09.003

Article (Scientific journals)

Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin beta is the true human homologue of rat thymosin beta 15

Dhaese, S.; Jonckheere, V.; Goethals, M. et al.

2007 • In FEBS Letters, 581 (25), p. 4809-4815

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/4710

DOI
10.1016/j.febslet.2007.09.003

PubMed
17888914

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Keywords :

thymosin; prostate; cancer; actin; cytoskeleton; cell migration

Abstract :

[en] A peptide with a sequence identical to rat thymosin beta(Tb)15 was reported to be upregulated in human prostate cancer. However, in this report we provide evidence that TbNB, initially identified in human neuroblastoma, is the only Tb isoform upregulated in human prostate cancer and that the Tb15 sequence is not present herein. In addition, we demonstrate that human TbNB has a higher affinity for actin in comparison to Tb4 and promotes cell migration. In combination, this experimentally validates TbNB as functional homologue of rat Tb15 in the human organism and clarifies the current composition of the human Tb family. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Dhaese, S.

Jonckheere, V.

Goethals, M.

Waltregny, David ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Labo de recherche sur les métastases

Vandekerckhove, J.

Ampe, C.

Van Troys, M.

Language :

English

Title :

Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin beta is the true human homologue of rat thymosin beta 15

Publication date :

16 October 2007

Journal title :

FEBS Letters

ISSN :

0014-5793

eISSN :

1873-3468

Publisher :

Elsevier Science Bv, Amsterdam, Netherlands

Volume :

581

Issue :

Pages :

4809-4815

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 January 2009

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