[en] By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular hypertrophy of the same magnitude as that observed for constitutive myostatin knockout mice. This formally demonstrates that striated muscle is the production site of functional myostatin and that this member of the TGFbeta family of growth and differentiation factors regulates muscle mass not only during early embryogenesis but throughout development. It indicates that myostatin antagonist could be used to treat muscle wasting and to promote muscle growth in man and animals.
Disciplines :
Genetics & genetic processes Veterinary medicine & animal health
Author, co-author :
Grobet, Luc ; Université de Liège - ULiège > Département de productions animales > Génétique
Pirottin, Dimitri ; Université de Liège - ULiège > Département de productions animales > Génétique
Farnir, Frédéric ; Université de Liège - ULiège > Département de productions animales > Biostatistique, économie, sélection animale
Poncelet, Dominique; Université de Liège - ULiège > Département de productions animales > Génétique
Royo, Luis Jose; Université de Liège - ULiège > Département de productions animales > Génétique
Brouwers, Benoît ; Université de Liège - ULiège > Département de productions animales > Génétique
Christians, Elisabeth; Université de Liège - ULiège > Département de morphologie et pathologie > Histologie et embryologie
Desmecht, Daniel ; Université de Liège - ULiège > Département de morphologie et pathologie > Pathologie spéciale et autopsies
Coignoul, Freddy ; Université de Liège - ULiège > Département de morphologie et pathologie > Pathologie générale et autopsies
Kahn, Ronald; Harvard Medical School > Department of Medicine > Joslin Diabetes Center
Georges, Michel ; Université de Liège - ULiège > Département de productions animales > Génétique
Language :
English
Title :
Modulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene.
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