Article (Scientific journals)
Exforge® (amlodipine/valsartan combination) in hypertension: the evidence of its therapeutic impact
Krzesinski, Jean-Marie; Cohen, Eric P.
2008In Core Evidence, 3 (2), p. 117-126
Peer reviewed
 

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Keywords :
arterial hypertension; treatment; combination therapy; calcium channel blocker; amlodipine; angiotensin II receptor; valsartan
Abstract :
[en] Abstract Introduction: Hypertension is an important risk factor for cardiovascular disease and its management requires improvement. New treatment strategies are needed. Aims: This review analyses one of these strategies, which is the development of effective and safe combination therapy. Indeed, at least two antihypertensive agents are often needed to achieve blood pressure control. Exforge® (Novartis) is a new drug combination of the calcium channel blocker, amlodipine, and the angiotensin II receptor blocker, valsartan. Evidence review: The amlodipine/valsartan combination is an association of two well-known antihypertensive products with specific targets in cardiovascular protection, namely calcium channel blockade and antagonism of the renin-angiotensin-aldosterone system. This kind of association, with neutral metabolic properties and significant antihypertensive efficacy, could be a useful new antihypertensive product. Currently available data have shown that this new combination is well-tolerated and effective even in severe hypertension. Clinical value: Clinical trials are ongoing for further assessment of the efficacy, compliance, and safety of this combination and its congeners. No data exist to prove that the amlodipine/valsartan combination is better than other antihypertensive strategies for cardiovascular or renal protection, but some trials with other combination therapies show such potential advantage.
Disciplines :
Urology & nephrology
Author, co-author :
Krzesinski, Jean-Marie ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Cohen, Eric P.;  Medical College of Wisconsin, Milwaukee, Wisconsin - USA > Nephrology Division
Language :
English
Title :
Exforge® (amlodipine/valsartan combination) in hypertension: the evidence of its therapeutic impact
Publication date :
2008
Journal title :
Core Evidence
ISSN :
1555-1741
eISSN :
1555-175X
Publisher :
Core Medical Publishing
Volume :
3
Issue :
2
Pages :
117-126
Peer reviewed :
Peer reviewed
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