Exforge® (amlodipine/valsartan combination) in hypertension: the evidence of its therapeutic impact

Krzesinski, Jean-Marie; Cohen, Eric P.

doi:10.3355/ce.2008.017

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Exforge® (amlodipine/valsartan combination) in hypertension: the evidence of its therapeutic impact

Krzesinski, Jean-Marie; Cohen, Eric P.

2008 • In Core Evidence, 3 (2), p. 117-126

Peer reviewed

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https://hdl.handle.net/2268/4217

DOI
10.3355/ce.2008.017

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Keywords :

arterial hypertension; treatment; combination therapy; calcium channel blocker; amlodipine; angiotensin II receptor; valsartan

Abstract :

[en] Abstract Introduction: Hypertension is an important risk factor for cardiovascular disease and its management requires improvement. New treatment strategies are needed. Aims: This review analyses one of these strategies, which is the development of effective and safe combination therapy. Indeed, at least two antihypertensive agents are often needed to achieve blood pressure control. Exforge® (Novartis) is a new drug combination of the calcium channel blocker, amlodipine, and the angiotensin II receptor blocker, valsartan. Evidence review: The amlodipine/valsartan combination is an association of two well-known antihypertensive products with specific targets in cardiovascular protection, namely calcium channel blockade and antagonism of the renin-angiotensin-aldosterone system. This kind of association, with neutral metabolic properties and significant antihypertensive efficacy, could be a useful new antihypertensive product. Currently available data have shown that this new combination is well-tolerated and effective even in severe hypertension. Clinical value: Clinical trials are ongoing for further assessment of the efficacy, compliance, and safety of this combination and its congeners. No data exist to prove that the amlodipine/valsartan combination is better than other antihypertensive strategies for cardiovascular or renal protection, but some trials with other combination therapies show such potential advantage.

Disciplines :

Urology & nephrology

Author, co-author :

Krzesinski, Jean-Marie ; Université de Liège - ULiège > Département des sciences cliniques > Néphrologie

Cohen, Eric P.; Medical College of Wisconsin, Milwaukee, Wisconsin - USA > Nephrology Division

Language :

English

Title :

Exforge® (amlodipine/valsartan combination) in hypertension: the evidence of its therapeutic impact

Publication date :

2008

Journal title :

Core Evidence

ISSN :

1555-1741

eISSN :

1555-175X

Publisher :

Core Medical Publishing

Volume :

Issue :

Pages :

117-126

Peer reviewed :

Peer reviewed

Available on ORBi :

since 14 January 2009

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