Article (Scientific journals)
Le medicament du mois. L'aliskiren (Rasilez), inhibiteur direct de la renine.
Scheen, André; Pierard, Luc; Krzesinski, Jean-Marie
2008In Revue Médicale de Liège, 63 (9), p. 564-9
Peer reviewed
 

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Keywords :
Aliskiren; Renin; angiotensin; aldosterone system; Renin inhibitor; Hypertension; Heart failure; Nephropathy
Abstract :
[en] Aliskiren (Rasilez) is the first oral renin inhibitor. Its present indication is essential hypertension, as monotherapy or in combination with other antihypertensive agents (diuretic, calcium antagonist, ...). It may also be associated with an angiotensin converting enzyme inhibitor (or an AT1 angiotensin receptor antagonist) in order to benefit of a dual blockade of the renin-angiotensin-aldosterone system. The usual daily dose is 150 mg, to be increased up to 300 mg if necessary. New clinical trials are ongoing to validate this novel therapeutic approach in other indications such as congestive heart failure and diabetic nephropathy.
Disciplines :
Endocrinology, metabolism & nutrition
Urology & nephrology
Cardiovascular & respiratory systems
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Pierard, Luc ;  Centre Hospitalier Universitaire de Liège - CHU > Cardiologie
Krzesinski, Jean-Marie ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
Language :
French
Title :
Le medicament du mois. L'aliskiren (Rasilez), inhibiteur direct de la renine.
Alternative titles :
[fr] Aliskiren (Rasilez), direct renin inhibitor
Publication date :
2008
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
63
Issue :
9
Pages :
564-9
Peer reviewed :
Peer reviewed
Available on ORBi :
since 14 January 2009

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