Reference : Le medicament du mois. L'aliskiren (Rasilez), inhibiteur direct de la renine.
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
Human health sciences : Urology & nephrology
Human health sciences : Endocrinology, metabolism & nutrition
Le medicament du mois. L'aliskiren (Rasilez), inhibiteur direct de la renine.
[fr] Aliskiren (Rasilez), direct renin inhibitor
Scheen, André mailto [Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale >]
Pierard, Luc mailto [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]
Krzesinski, Jean-Marie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
Revue Médicale de Liège
Yes (verified by ORBi)
[en] Aliskiren ; Renin ; angiotensin ; aldosterone system ; Renin inhibitor ; Hypertension
[fr] Heart failure ; Nephropathy
[en] Aliskiren (Rasilez) is the first oral renin inhibitor. Its present indication is essential hypertension, as monotherapy or in combination with other antihypertensive agents (diuretic, calcium antagonist, ...). It may also be associated with an angiotensin converting enzyme inhibitor (or an AT1 angiotensin receptor antagonist) in order to benefit of a dual blockade of the renin-angiotensin-aldosterone system. The usual daily dose is 150 mg, to be increased up to 300 mg if necessary. New clinical trials are ongoing to validate this novel therapeutic approach in other indications such as congestive heart failure and diabetic nephropathy.
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