Determination of the Enantiomers of 3-Tert.-Butylamino-1,2-Propanediol by High-Performance Liquid Chromatography Coupled to Evaporative Light Scattering Detection
Toussaint, B.; Duchateau, A. L.; van der Wal, S.et al.
2000 • In Journal of Chromatography. A, 890 (2), p. 239-49
[en] A method for the separation and quantitation of the enantiomers of 3-tert.-butylamino-1,2-propanediol by high-performance liquid chromatography and evaporative light scattering detection has been developed. Separation of the enantiomers was performed in normal-phase liquid chromatography on a Chiralpak AS chiral stationary phase. The influence of the gas nature, gas pressure and temperature of the drift tube of the evaporative light scattering detector on the detection sensitivity was investigated. The method was validated in terms of linearity, limit of quantitation, accuracy and precision. The enantiomeric excess of (S)-3-tert.-butylamino-1,2-propanediol, used for the industrial synthesis of (S)-timolol, was measured from 0 to 94%.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Toussaint, B.
Duchateau, A. L.
van der Wal, S.
Albert, Adelin ; Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
Crommen, Jacques ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Language :
English
Title :
Determination of the Enantiomers of 3-Tert.-Butylamino-1,2-Propanediol by High-Performance Liquid Chromatography Coupled to Evaporative Light Scattering Detection
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