Influence of Melting and Rheological Properties of Fatty Binders on the Melt Granulation Process in a High-Shear Mixer

[en] The preparation of granules by melt granulation was investigated using a laboratory-scale high-shear mixer (Pellmix PL 1/8) and binary mixtures containing lactose and different lipidic binders, namely, Compritol 888, Cutina HR, or Precirol ATO5.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Evrard, Brigitte ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique

Amighi, K.

Beten, D.

Delattre, Luc ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie

Moes, A. J.

Language :

English

Title :

Influence of Melting and Rheological Properties of Fatty Binders on the Melt Granulation Process in a High-Shear Mixer

Publication date :

November 1999

Journal title :

Drug Development and Industrial Pharmacy

ISSN :

0363-9045

eISSN :

1520-5762

Publisher :

Marcel Dekker, New York, United States - New York

Volume :

Issue :

Pages :

1177-84

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 28 April 2010

Statistics

Number of views

81 (0 by ULiège)

Number of downloads

0 (0 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

T. Schaefer, P. Holm, and H. G. Kristensen, Drug Dev. Ind. Pharm., 16, 1249-1277 (1990).
T. Shaefer and Ch. Mathiesen, Int. J. Pharm., 134, 105-117 (1996).
T. Schaefer, B. Taagegaard, L. J. Thomsen, and H. G. Kristensen, Eur. J. Pharm. Sci., 1, 125-131 (1993).
T. Schaefer and Ch. Mathiesen, Int. J. Pharm., 139, 125-138 (1996).
R. Kinget and R. Kernel, Acta Pharm. Technol., 31, 57-62 (1985).
C. A. McTaggart, J. A. Ganley, A. Sickmueller, and S. E. Walker, Int. J. Pharm., 19, 139-148 (1984).
P. Flanders, G. A. Dyer, and D. Jordan, Drug Dev. Ind. Pharm., 13, 1001-1022 (1987).
L. J. Thomsen, T. Schaefer, J. Sonnergaard, and H. G. Kristensen, Drug Dev. Ind. Pharm., 19, 1867-1887 (1993).
B. Evrard and L. Delattre, Drug Dev. Ind. Pharm., 22, 111-118 (1996).
P. V. Parab, C. K. Oh, and W. A. Ritschel, Drug Dev. Ind. Pharm., 12, 1309-1327 (1986).
D. Saraiya and S. Bolton, Drug Dev. Ind. Pharm., 16, 1963-1969 (1990).
S. Malamataris, A. Panagopoulou, and P. Hatzipantou, Drug Dev. Ind. Pharm., 17, 1765-1777 (1991).
M. H. Rubinstein and P. Musikabhuma, Drug Dev. Ind. Pharm., 6, 451-473 (1980).
B. Evrard and L. Delattre, Proc. 6th Int. Conf. Pharm. Technol., 187-196 (1992).
M. G. Boles, P. B. Deasy, and M. F. Donnellan, Drug Dev. Ind. Pharm., 19, 349-370 (1993).
A. N. Ozdemir and I. Agabeyoglu, Drug Dev. Ind. Pharm., 16, 1805-1814 (1990).
A. M. Pommier, C. Brossard, J. Ser, and D. Duchêne, STP Pharma, 4, 384-391 (1988).
H. Bier, H. Leuenberger, and H. Sucker, Pharm. Ind., 41, 375-380 (1979).
P. Holm, High shear mixer granulators, in Handbook of Pharmaceutical Granulation Technology. Drugs and Pharmaceutical Science, Vol. 81 (D. M. Parikh, Ed.), Marcel Dekker, New York, 1997, pp. 151-204.
B. Evrard, Ph.D. thesis, Universite' de Liège, 1995.
C. K. Schoff, Rheological measurements, in Polymers: Polymer Characterization and Analysis (J. I. Kroschwits, Ed.), Wiley Interscience, New York, 1990, pp. 637-725.
M. Djimbo and A. J. Moës, J. Pharm. Belg., 39, 36-42 (1984).
A. J. Moës, Pharm. Acta Helv., 43, 290-320 (1968).