Article (Scientific journals)
Enantiomeric separation of aminoglutethimide by capillary electrophoresis using native cyclodextrins in single and dual systems
Abushoffa, A. M.; Fillet, Marianne; Marini Djang'Eing'A, Roland et al.
2003In Journal of Separation Science, 26 (6-7), p. 536-542
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Keywords :
enantioseparation; cyclodextrins; dual systems; aminoglutethimide; capillary electrophoresis
Abstract :
[en] Aminoglutethimide (AGT) is one of the few examples of chiral drugs that can be enantioseparated by capillary electrophoresis using any of the three native cyclodextrins: alpha-, beta-, or gamma-CD. A complete resolution of the enantiomers of this compound in cationic form could be achieved with each of the three CDs, using a pH 3 phosphoric acid-triethanolamine buffer. Affinity constants for AGT enantiomers with the three native CDs were determined, confirming that the highest selectivity was given by gamma-CD while the strongest complexation was obtained with beta-CD. However, an opposite affinity pattern was observed with the latter. Selectivity was lower for AGT enantiomers in dual CD systems, compared to that obtained with a single selector at its optimal concentration, which confirms that dual systems are of more limited interest when the two selectors have a similar effect on the analyte mobility. These results are in good agreement with those predicted using recently developed mathematical models.
Research Center/Unit :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Abushoffa, A. M.
Fillet, Marianne  ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Marini Djang'Eing'A, Roland ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Hubert, Philippe  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Crommen, Jacques ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Language :
English
Title :
Enantiomeric separation of aminoglutethimide by capillary electrophoresis using native cyclodextrins in single and dual systems
Publication date :
2003
Journal title :
Journal of Separation Science
ISSN :
1615-9306
eISSN :
1615-9314
Publisher :
Wiley-VCH Verlag Gmbh, Weinheim, Germany
Volume :
26
Issue :
6-7
Pages :
536-542
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique
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