Article (Scientific journals)
Medications in the kidney.
Scheen, André
2008In Acta Clinica Belgica, 63 (2), p. 76-80
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Keywords :
Anti-Bacterial Agents/administration & dosage/pharmacokinetics; Dose-Response Relationship, Drug; Glomerular Filtration Rate/drug effects; Humans; Kidney Failure, Chronic/drug therapy/metabolism; Kidney Tubules/drug effects/metabolism; Treatment Outcome
Abstract :
[en] Patients with chronic kidney disease (CKD) constitute a population at high risk for adverse drug reactions and/or drug-drug interactions. Renal dysfunction-induced pathophysiological changes may alter both medication pharmacodynamics and handling. Most pharmacokinetic parameters are adversely affected by impaired kidney function, among which reduced glomerular filtration and altered tubular secretion and reabsorption lead to the most specific alterations. Dosages of drugs cleared by the kidney should usually be adjusted according to creatinine clearance. Recommended methods for maintenance dosing adjustments are dose reductions, lengthening the dosing interval, or both. Appropriate drug selection and dosing in patients with CKD is imperative to avoid drug adverse events and to ensure optimal patient outcomes.
Disciplines :
Urology & nephrology
Pharmacy, pharmacology & toxicology
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
English
Title :
Medications in the kidney.
Publication date :
2008
Journal title :
Acta Clinica Belgica
ISSN :
0001-5512
Publisher :
Acta Clinica Belgica, Bruxelles, Belgium
Volume :
63
Issue :
2
Pages :
76-80
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 January 2009

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