Haplophyllum foliosum; H. pedicellatum; Rutaceae; new quinoline alkaloid folipidine; chemical transformations; spectral data (UV, IR, mass, NMR, 2D(1)H-H-1 COSY, NOESY, H-1-C-13 HSQC, HMBC); antitumor activity
Abstract :
[en] The new quinoline alkaloid folipidine, the structure of which was established by chemical transformations and spectral data (UV, IR, mass, NMR) using APT 2D H-1-H-1 COSY, NOESY, and H-1-(13)CHSQC, HMBC, was isolated from two plants of the Haplophyllum mints. Folipidine is the first representative of a new type of quinoline alkaloids that contain a heteroaromatic skeleton of [3,4-b]conjugated pyrrole and quinoline fragments. The total alkaloids of these plants exhibit antitumor activity. Folipidine does not possess such activity.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Akhmedzhanova, V. I.
Rasulova, K. A.
Bessonova, I. A.
Shashkov, A. S.
Abdullaev, N. D.
Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Folipidine, a new type quinoline alkaloid from plants of the Haplophyllum genus
Publication date :
2005
Journal title :
Chemistry of Natural Compounds
ISSN :
0009-3130
eISSN :
1573-8388
Publisher :
Kluwer Academic/Plenum Publishers, New York, United States - New York
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