Article (Scientific journals)
Long-term effects of JL 13, a potential atypical antipsychotic, on Ionotropic glutamate receptors
Tarazi, Frank I.; Moran-Gates, Taylor; Gardner, Matthew P. et al.
2007In Journal of Molecular Neuroscience, 32 (3), p. 192-198
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Keywords :
autoradiography; antipsychotic drugs; caudate-putamen; glutamate receptors; hippocampus
Abstract :
[en] Changes in ionotropic glutamate (Glu) N-methyl-D-aspartic acid (NMDA), and 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptors in rat forebrain regions were autoradiographically quantified after continuous infusion of JL 13 [(5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine furnarate] for 28 days using osmotic minipumps, and compared to the effects of representative typical (haloperidol) and atypical (clozapine, olanzapine, and risperidone) antipsychotic drugs from previous studies. Similar to other atypical and not typical antipsychotics, JL 13 decreased labeling of NMDA receptors in medial and lateral caudate-putamen (CPu; by 40%). These findings indicate that downregulation of NMDA receptors by JL 13 and other atypical antipsychotic agents in CPu may contribute to their low risk of extrapyramidal side effects. In addition, and similar to olanzapine and risperidone, JL 13 increased AMPA receptor binding in CPu (by 42%). Changes in AMPA receptors may contribute to psychopharmacological properties of JL 13 and other atypical agents. Similar to clozapine, JL 13 did not alter levels of NMDA and AMPA receptors in hippocampus and entorhinal cortex. Long-term effects of JL 13 on ionotropic Glu receptors, as well as on other dopamine and serotonin receptors, support the atypical antipsychotic profile of this novel agent.
Disciplines :
Neurosciences & behavior
Biochemistry, biophysics & molecular biology
Author, co-author :
Tarazi, Frank I.
Moran-Gates, Taylor
Gardner, Matthew P.
Graulich, Amaury ;  Université de Liège - ULiège > Chimie pharmaceutique
Lamy, Cédric ;  Université de Liège - ULiège > Pharmacologie
Liégeois, Jean-François ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Language :
English
Title :
Long-term effects of JL 13, a potential atypical antipsychotic, on Ionotropic glutamate receptors
Publication date :
2007
Journal title :
Journal of Molecular Neuroscience
ISSN :
0895-8696
eISSN :
1559-1166
Publisher :
Humana Press Inc, Totowa, United States - New Jersey
Volume :
32
Issue :
3
Pages :
192-198
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 January 2009

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