Adolescent; Adult; Asthma/complications/*genetics; Bronchial Hyperreactivity/etiology/*genetics; Child; Child, Preschool; *Fathers; Female; Humans; Male; Medical History Taking; Severity of Illness Index
Abstract :
[en] RATIONALE: Little is known regarding the relationship between parental history of asthma and subsequent airway hyperresponsiveness (AHR) in children with asthma. OBJECTIVES: We evaluated this relationship in 1,041 children with asthma participating in a randomized trial of antiinflammatory medications (the Childhood Asthma Management Program [CAMP]). METHODS: Methacholine challenge testing was performed before treatment randomization and once per year over an average of 4.5 years postrandomization. Cross-sectional and longitudinal repeated measures analyses were performed to model the relationship between PC20 (the methacholine concentration causing a 20% fall in FEV1) with maternal, paternal, and joint parental histories of asthma. Models were adjusted for potential confounders. MEASUREMENTS AND MAIN RESULTS: At baseline, AHR was strongly associated with a paternal history of asthma. Children with a paternal history of asthma demonstrated significantly greater AHR than those without such history (median log(e)PC20, 0.84 vs. 1.13; p = 0.006). Although maternal history of asthma was not associated with AHR, children with two parents with asthma had greater AHR than those with no parents with asthma (median log(e)PC20, 0.52 vs. 1.17; p = 0.0008). Longitudinal multivariate analysis of the relation between paternal history of asthma and AHR using repeated PC20 measurements over 44 months postrandomization confirmed a significant association between paternal history of asthma and AHR among children in CAMP. CONCLUSIONS: Our findings suggest that the genetic contribution of the father is associated with AHR, an important determinant of disease severity among children with asthma.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Raby, B. A.
Van Steen, Kristel ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique
Celedon, J. C.
Litonjua, A. A.
Lange, C.
Weiss, S. T.
Language :
English
Title :
Paternal history of asthma and airway responsiveness in children with asthma
Publication date :
2005
Journal title :
American Journal of Respiratory and Critical Care Medicine
ISSN :
1073-449X
eISSN :
1535-4970
Publisher :
American Thoracic Society, New York, United States - New York
National Institutes of Health. Global initiative for asthma. Bethesda, MD: National Heart, Lung, and Blood Institute; 2004. Publication No. 95-3659.
Weiss ST, Van Natta ML, Zeiger RS. Relationship between increased airway responsiveness and asthma severity in the childhood asthma management program. Am J Respir Crit Care Med 2000;162:50-56.
Sears MR, Greene JM, Willan AR, Wiecek EM, Taylor DR, Flannery EM, Cowan JO, Herbison GP, Silva PA, Poulton R. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 2003;349:1414-1422.
Sherrill D, Sears MR, Lebowitz MD, Holdaway MD, Hewitt CJ, Flannery EM, Herbison GP, Silva PA. The effects of airway hyperresponsiveness, wheezing, and atopy on longitudinal pulmonary function in children: a 6-year follow-up study. Pediatr Pulmonol 1992;13:78-85.
Grol MH, Gerritsen J, Vonk JM, Schouten JP, Koeter GH, Rijcken B, Postma DS. Risk factors for growth and decline of lung function in asthmatic individuals up to age 42 years: a 30-year follow-up study. Am J Respir Crit Care Med 1999;160:1830-1837.
Childhood Asthma Management Program Research Group. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 2000;343:1054-1063.
Palmer LJ, Burton PR, Faux JA, James AL, Musk AW, Cookson WO. Independent inheritance of serum immunoglobulin E concentrations and airway responsiveness. Am J Respir Crit Care Med 2000;161:1836-1843.
Peat JK, Britton WJ, Salome CM, Woolcock AJ. Bronchial hyperresponsiveness in two populations of Australian schoolchildren: II. Relative importance of associated factors. Clin Allergy 1987;17:283-290.
Wilson NM, Dore CJ, Silverman M. Factors relating to the severity of symptoms at 5 yrs in children with severe wheeze in the first 2 yrs of life. Eur Respir J 1997;10:346-353.
Young S, Le Souef PN, Geelhoed GC, Stick SM, Turner KJ, Landau LI. The influence of a family history of asthma and parental smoking on airway responsiveness in early infancy. N Engl J Med 1991;324:1168-1173.
Childhood Asthma Management Program Research Group. The Childhood Asthma Management Program (CAMP): design, rationale, and methods. Control Clin Trials 1999;20:91-120.
Searle S. Linear models for unbalanced data. New York: John Wiley & Sons; 1987.
Hosmer D, Lemeshow S. Applied logistic regression. New York: John Wiley & Sons; 1989.
Singer JD. Using SAS PROC MIXED to fit multilevel models, hierarchical models, and individual growth models. J Educ Behav Stat 1998;24: 323-355.
Diggle PJ, Heagerty P, Linang KY, Zeger SL. Analysis of longitudinal data, 2nd ed. Oxford, UK: Oxford University Press; 2002. Oxford Statistical Science Series 25.
SAS/STAT user's guide, version 8. Cary, NC: SAS Institute; 1999.
Moffatt MF, Cookson WO. The genetics of asthma: maternal effects in atopic disease. Clin Exp Allergy 1998;28:56-61. [Discussion: 65-56].
Kuehr J, Karmaus W, Forster J, Frischer T, Hendel-Kramer A, Moseler M, Stephan V, Urbanek R, Weiss K. Sensitization to four common inhalant allergens within 302 nuclear families. Clin Exp Allergy 1993; 23:600-605.
Bray GW. The heredity factor in hypersensitiveness, anaphylaxis and allergy. J Allergy 1931;2:203-204.
Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life: the Group Health Medical Associates. N Engl J Med 1995;332:133-138.
Sherriff A, Peters TJ, Henderson J, Strachan D. Risk factor associations with wheezing patterns in children followed longitudinally from birth to 3(1/2) years. Int J Epidemiol 2001;30:1473-1484.
Gold DR, Burge HA, Carey V, Milton DK, Platts-Mills T, Weiss ST. Predictors of repeated wheeze in the first year of life: the relative roles of cockroach, birth weight, acute lower respiratory illness, and maternal smoking. Am J Respir Crit Care Med 1999;160:227-236.
Celedon JC, Wright RJ, Litonjua AA, Sredl D, Ryan L, Weiss ST, Gold DR. Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 years. Am J Respir Crit Care Med 2003;167: 1239-1243.
Celedon JC, Litonjua AA, Ryan L, Platts-Mills T, Weiss ST, Gold DR. Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life. Lancet 2002;360:781-782.
Gray L, Peat JK, Belousova E, Xuan W, Woolcock AJ. Family patterns of asthma, atopy and airway hyperresponsiveness: an epidemiological study. Clin Exp Allergy 2000;30:393-399.
Kurzius-Spencer M, Holberg CJ, Sherrill DL, Carrozzi L, Di Pede F, Baldacci S, Viegi G. Segregation analysis of bronchial hyperresponsiveness in a general population in north Italy. Am J Med Genet 2004; 125A:232-239.
Jenkins MA, Hopper JL, Bowes G, Carlin JB, Flander LB, Giles GG. Factors in childhood as predictors of asthma in adult life. BMJ 1994; 309:90-93.
Aberg N. Familial occurrence of atopic disease: genetic versus environmental factors. Clin Exp Allergy 1993;23:829-834.
Dold S, Wjst M, von Mutius E, Reitmeir P, Stiepel E. Genetic risk for asthma, allergic rhinitis, and atopic dermatitis. Arch Dis Child 1992; 67:1018-1022.
Litonjua AA, Carey VJ, Burge HA, Weiss ST, Gold DR. Parental history and the risk for childhood asthma: does mother confer more risk than father? Am J Respir Crit Care Med 1998;158:176-181.
Raby BA, Lazarus R, Silverman EK, Lake S, Lange C, Wjst M, Weiss ST. Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med 2004;170:1057-1065.
Skobeloff EM, Spivey WH, St Clair SS, Schoffstall JM. The influence of age and sex on asthma admissions. JAMA 1992;268:3437-3440.
Moreno C, Dumas P, Kaldunski ML, Tonellato PJ, Greene AS, Roman RJ, Cheng Q, Wang Z, Jacob HJ, Cowley AW Jr. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiol Genomics 2003;15:243-257.
Leaves NI, Bhattacharyya S, Wiltshire S, Cookson WO. A detailed genetic map of the chromosome 7 bronchial hyper-responsiveness locus. Eur J Hum Genet 2002;10:177-182.
Laitinen T, Polvi A, Rydman P, Vendelin J, Pulkkinen V, Salmikangas P, Makela S, Rehn M, Pirskanen A, Rautanen A, et al. Characterization of a common susceptibility locus for asthma-related traits. Science 2004;304:300-304.
Pin I, Siroux V, Cans C, Kauffmann F, Maccario J, Pison C, Dizier MH. Familial resemblance of asthma severity in the EGEA study. Am J Respir Crit Care Med 2002;165:185-189.
Xu X, Fang Z, Wang B, Chen C, Guang W, Jin Y, Yang J, Lewitzky S, Aelony A, Parker A, et al. A genomewide search for quantitative-trait loci underlying asthma. Am J Hum Genet 2001;69:1271-1277.
Postma DS, de Vries K, Koeter GH, Sluiter HJ. Independent influence of reversibility of air-flow obstruction and nonspecific hyperreactivity on the long-term course of lung function in chronic air-flow obstruction. Am Rev Respir Dis 1986;134:276-280.
Malerba G, Trabetti E, Patuzzo C, Lauciello MC, Galavotti R, Pescollderungg L, Boner AL, Pignatti PF. Candidate genes and a genome-wide search in Italian families with atopic asthmatic children. Clin Exp Allergy 1999;29:27-30.
Raby BA, Silverman EK, Lazarus R, Lange C, Kwiatkowski DJ, Weiss ST. Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes. Hum Mol Genet 2003;12:1973-1979.
Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, Torrey D, Pandit S, McKenny J, Braunschweiger K, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 2002;418:426-430.
Weinberg CR, Wilcox AJ, Lie RT. A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet 1998;62:969-978.
