Article (Scientific journals)
Crohn's disease and month of birth.
Van Ranst, Marc; Joossens, Marie; Joossens, Sofie et al.
2005In Inflammatory Bowel Diseases, 11 (6), p. 597-9
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Keywords :
Adolescent; Adult; Aged; Belgium/epidemiology; Birth Certificates; Cohort Studies; Crohn Disease/epidemiology/etiology/prevention & control; Female; Humans; Male; Middle Aged; Odds Ratio; Parturition; Periodicity; Risk Factors; Seasons
Abstract :
[en] BACKGROUND: Environmental factors trigger the onset of inflammatory bowel disease (IBD) in genetically predisposed individuals. Exposure to seasonal external factors during the maturation of the immune system is suspected to be an inducing factor for IBD. Some studies suggested an association between the month of birth and the later development of IBD. We studied this putative relationship in a large cohort of Belgian patients with Crohn's disease (CD). METHODS: Data from 1025 patients born between 1935 and 1990 were collected. Diagnosis of CD was based on generally accepted clinical, endoscopic, and histologic criteria. As a control group, a cohort of 5125 non-IBD patients seen at the same hospital and matched for birth year and sex was used. Odds ratios were calculated using multivariate unconditional logistic regression including the matching variables and allowing for cyclic variation in risk with month of birth. RESULTS: A cyclic pattern described by a 4-month periodic function was observed with peaks in April and August. Moreover, being born in June significantly reduced the risk of developing CD later in life (P = 0.012). CONCLUSION: In this Belgian cohort, a significant association was found between the month of birth and later development of IBD; a significant reduced risk to develop CD was observed for people born in June. Moreover, environmental yearly reoccurring factors during pregnancy or postpartum might be associated with the occurrence of CD later in life.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Van Ranst, Marc
Joossens, Marie
Joossens, Sofie
Van Steen, Kristel  ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique
Pierik, Marieke
Vermeire, Severine
Rutgeerts, Paul
Language :
English
Title :
Crohn's disease and month of birth.
Publication date :
2005
Journal title :
Inflammatory Bowel Diseases
ISSN :
1078-0998
eISSN :
1536-4844
Publisher :
Lippincott Williams & Wilkins, Hagerstown, United States - Maryland
Volume :
11
Issue :
6
Pages :
597-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 May 2010

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