Article (Scientific journals)
Strychnopentamine
Angenot, Luc
1986In Drugs of the Future, 11 (1), p. 42-44
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Keywords :
strychnopentamine; isolation and structure; description; history; pharmacological activity
Abstract :
[en] Strychnopentamine is a new alkaloid found in Strychnos usambarensis leaves. It is the first alkaloid with five amines found in a Strychnos species; a methylpyrrolidinic group is joined to a bnzene ring of the corynane part of the molecule.Antimitotic activity tests were carried out on cultured HW165 hepatoma, B16 melanoma and Ehrlich ascites cells.Strychnopentamine was more active than other indole alkaloids isolated from the same species.Preliminary experiments were then undertaken to search for a possible antitumor activity in animals (Ehrlich ascites tumor cells in mice).At a single dose of 2mg, a very marked regression was obvious but mice showed signs of intoxication. Other experiments must be carried out , in order to establish a more exact structure-activity relationship and to discover less toxic substances.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Strychnopentamine
Publication date :
January 1986
Journal title :
Drugs of the Future
ISSN :
0377-8282
Publisher :
Prous Science, Barcelona, Spain
Volume :
11
Issue :
1
Pages :
42-44
Peer reviewed :
Peer reviewed
Available on ORBi :
since 20 May 2010

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