O Andreoletti P Berthon D Marc P Sarradin J Grosclaude KL van F Schelcher JM Elsen F Lantier 2000 Early accumulation of PrP(Sc) in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie J Gen Virol 81 3115 3126 1:CAS:528:DC%2BD3cXptVWmsrw%3D 11086143
P Aucouturier F Geissmann D Damotte GP Saborio HC Meeker R Kascsak R Kascsak RI Carp T Wisniewski 2001 Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie J Clin Invest 108 703 708 1:CAS:528:DC%2BD3MXmsFKrtLs%3D 11544275
M Beekes PA McBride 2007 The spread of prions through the body in naturally acquired transmissible spongiform encephalopathies FEBS J 274 588 605 10.1111/j.1742-4658.2007.05631.x 1:CAS:528:DC%2BD2sXitVOhtL8%3D 17288548 (Pubitemid 46150854)
R Berthier C Martinon-Ego AM Laharie PN Marche 2000 A two-step culture method starting with early growth factors permits enhanced production of functional dendritic cells from murine splenocytes J Immunol Methods 239 95 107 10.1016/S0022-1759(00)00186-1 1:CAS:528:DC%2BD3cXjt1aqsL0%3D 10821951 (Pubitemid 30256022)
T Blattler S Brandner AJ Raeber MA Klein T Voigtlander C Weissmann A Aguzzi 1997 PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain Nature 389 69 73 10.1038/37981 1:CAS:528:DyaK2sXlvVClu7g%3D 9288968 (Pubitemid 27387692)
ME Bruce PA McBride CF Farquhar 1989 Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie Neurosci Lett 102 1 6 10.1016/0304-3940(89)90298-X 1:STN:280: DyaL1MzosFamsg%3D%3D 2550852 (Pubitemid 19163144)
H Bueler A Aguzzi A Sailer RA Greiner P Autenried M Aguet C Weissmann 1993 Mice devoid of PrP are resistant to scrapie Cell 73 1339 1347 10.1016/0092-8674(93)90360-3 1:CAS:528:DyaK3sXkvFaltbk%3D 8100741 (Pubitemid 23201147)
B Caughey GS Baron 2006 Prions and their partners in crime Nature 443 803 810 10.1038/nature05294 1:CAS:528:DC%2BD28XhtVyktbbI 17051207 (Pubitemid 44622685)
R Chiocchetti, et al. 2006 Anatomical evidence for ileal Peyer's patches innervation by enteric nervous system: A potential route for prion neuroinvasion? Cell Tissue Res 332 2 185 194 10.1007/s00441-008-0583-y
FE Cohen SB Prusiner 1998 Pathologic conformations of prion proteins Annu Rev Biochem 67 793 819 10.1146/annurev.biochem.67.1.793 1:CAS:528: DyaK1cXlsFOmsbc%3D 9759504 (Pubitemid 28411145)
S Cordier-Dirikoc J Chabry 2008 Temporary depletion of CD11c+ dendritic cells delays lymphoinvasion after intraperitonal scrapie infection J Virol 82 8933 8936 10.1128/JVI.02440-07 1:CAS:528:DC%2BD1cXhtVClt7rL 18579603
J Couzin 2005 Cell biology: The ins and outs of exosomes Science 308 1862 1863 10.1126/science.308.5730.1862 1:CAS:528:DC%2BD2MXlsF2kur0%3D 15976285 (Pubitemid 40941852)
SJ DeArmond Y Qiu H Sanchez PR Spilman A Ninchak-Casey D Alonso V Daggett 1999 PrPc glycoform heterogeneity as a function of brain region: implications for selective targeting of neurons by prion strains J Neuropathol Exp Neurol 58 1000 1009 10.1097/00005072-199909000-00010 1:CAS:528:DyaK1MXmsFOls7c%3D 10499442
V Defaweux G Dorban C Demonceau J Piret O Jolois O Thellin C Thielen E Heinen N Antoine 2005 Interfaces between dendritic cells, other immune cells, and nerve fibres in mouse Peyer's patches: potential sites for neuroinvasion in prion diseases Microsc Res Tech 66 1 9 10.1002/jemt.20135 1:CAS:528: DC%2BD2MXktVSjtLc%3D 15816033 (Pubitemid 40524887)
G Dorban V Defaweux C Demonceau S Flandroy PB Van Lerberghe N Falisse-Poirrier J Piret E Heinen N Antoine 2007 Interaction between dendritic cells and nerve fibres in lymphoid organs after oral scrapie exposure Virchows Arch 451 1057 1065 10.1007/s00428-007-0476-6 17823814 (Pubitemid 350165257)
G Dorban, et al. 2007 Oral scrapie infection modifies the homeostasis of Peyer's patches' dendritic cells Histochem Cell Biol 128 243 251 10.1007/s00418-007-0303-9 1:CAS:528:DC%2BD2sXpsFalsbc%3D 17622551 (Pubitemid 47313104)
I Dupiereux W Zorzi W Rachidi D Zorzi O Pierard B Lhereux E Heinen B Elmoualij 2006 Study on the toxic mechanism of prion protein peptide 106-126 in neuronal and non neuronal cells J Neurosci Res 84 637 646 10.1002/jnr.20965 1:CAS:528:DC%2BD28Xotlymsrk%3D 16786576 (Pubitemid 44196704)
B Fevrier D Vilette F Archer D Loew W Faigle M Vidal H Laude G Raposo 2004 Cells release prions in association with exosomes Proc Natl Acad Sci USA 101 9683 9688 10.1073/pnas.0308413101 1:CAS:528:DC%2BD2cXlvVahtr4%3D 15210972 (Pubitemid 38869296)
A Flores-Langarica Y Sebti DA Mitchell RB Sim GG MacPherson 2009 Scrapie pathogenesis: the role of complement C1q in scrapie agent uptake by conventional dendritic cells J Immunol 182 1305 1313 1:CAS:528:DC%2BD1MXnsVeltg%3D%3D 19155476
S Gauczynski D Nikles S El-Gogo D Papy-Garcia C Rey S Alban D Barritault CI Lasmezas S Weiss 2006 The 37-kDa/67-kDa laminin receptor acts as a receptor for infectious prions and is inhibited by polysulfated glycanes J Infect Dis 194 702 709 10.1086/505914 1:CAS:528:DC%2BD28XpvFejtL0%3D 16897671 (Pubitemid 44297858)
K Gousset, et al. 2009 Prions hijack tunnelling nanotubes for intercellular spread Nat Cell Biol 11 328 336 10.1038/ncb1841 1:CAS:528:DC%2BD1MXisVOlsb4%3D 19198598
FL Heppner AD Christ MA Klein M Prinz M Fried JP Kraehenbuhl A Aguzzi 2001 Transepithelial prion transport by M cells Nat Med 7 976 977 10.1038/nm0901-976 1:CAS:528:DC%2BD3MXmvFOnu7c%3D 11533681 (Pubitemid 32937358)
FP Huang GG MacPherson 2004 Dendritic cells and oral transmission of prion diseases Adv Drug Deliv Rev 56 901 913 10.1016/j.addr.2003.09.006 1:CAS:528:DC%2BD2cXivVGit7c%3D 15063597 (Pubitemid 38520106)
FP Huang CF Farquhar NA Mabbott ME Bruce GG MacPherson 2002 Migrating intestinal dendritic cells transport PrP(Sc) from the gut J Gen Virol 83 267 271 1:CAS:528:DC%2BD38Xlt1Gkug%3D%3D 11752724
N Iwata, et al. 2006 Distribution of PrP(Sc) in cattle with bovine spongiform encephalopathy slaughtered at abattoirs in Japan Jpn J Infect Dis 59 100 107 1:CAS:528:DC%2BD28Xmt1ygu7w%3D 16632909
M Jeffrey, et al. 2006 Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep J Pathol 209 4 14 10.1002/path.1962 1:CAS:528:DC%2BD28XkvVSmt7c%3D 16575799
BL Kelsall M Rescigno 2004 Mucosal dendritic cells in immunity and inflammation Nat Immunol 5 1091 1095 10.1038/ni1104-1091 1:CAS:528: DC%2BD2cXoslSksLk%3D 15496943 (Pubitemid 39549618)
RH Kimberlin CA Walker 1989 The role of the spleen in the neuroinvasion of scrapie in mice Virus Res 12 201 211 10.1016/0168-1702(89)90039-7 1:STN:280:DyaL1M3mvFSkuw%3D%3D 2499134 (Pubitemid 19088146)
C Kratzel J Mai K Madela M Beekes D Kruger 2007 Propagation of scrapie in peripheral nerves after footpad infection in normal and neurotoxin exposed hamsters Vet Res 38 127 139 10.1051/vetres:2006047 1:CAS:528: DC%2BD2sXhvVajs7w%3D 17181988
T Kuczius I Haist MH Groschup 1998 Molecular analysis of bovine spongiform encephalopathy and scrapie strain variation J Infect Dis 178 693 699 10.1086/515337 1:CAS:528:DyaK1cXlvVyksLs%3D 9728537
P Leblanc S Alais I Porto-Carreiro S Lehmann J Grassi G Raposo JL Darlix 2006 Retrovirus infection strongly enhances scrapie infectivity release in cell culture EMBO J 25 2674 2685 10.1038/sj.emboj.7601162 1:CAS:528: DC%2BD28XlvFKhsL4%3D 16724107 (Pubitemid 43980376)
KM Luhr RP Wallin HG Ljunggren P Low A Taraboulos K Kristensson 2002 Processing and degradation of exogenous prion protein by CD11c(+) myeloid dendritic cells in vitro J Virol 76 12259 12264 10.1128/JVI.76.23.12259-12264. 2002 1:CAS:528:DC%2BD38Xos12qt78%3D 12414965 (Pubitemid 35304323)
KM Luhr EK Nordstrom P Low HG Ljunggren A Taraboulos K Kristensson 2004 Scrapie protein degradation by cysteine proteases in CD11c+ dendritic cells and GT1-1 neuronal cells J Virol 78 4776 4782 10.1128/JVI.78.9.4776-4782.2004 1:CAS:528:DC%2BD2cXjsVKisLk%3D 15078959 (Pubitemid 38501098)
B Ma WR von W Lindenmaier KE Dittmar 2007 Immmunohistochemical study of the blood and lymphatic vasculature and the innervation of mouse gut and gut-associated lymphoid tissue Anat Histol Embryol 36 62 74 10.1111/j.1439-0264. 2006.00741.x 1:STN:280:DC%2BD2s%2Fmt1Wjtw%3D%3D 17266671 (Pubitemid 46192825)
G Marruchella, et al. 2007 Enteroglial and neuronal involvement without apparent neuron loss in ileal enteric nervous system plexuses from scrapie-affected sheep J Gen Virol 88 2899 2904 10.1099/vir.0.82907-0 1:CAS:528:DC%2BD2sXhtFKrtLnN 17872545 (Pubitemid 47555046)
G Marruchella, et al. 2009 Ileal tract and Peyer's patch innervation in scrapie-free versus scrapie-affected ovines Arch Virol 154 709 714 10.1007/s00705-009-0361-5 1:CAS:528:DC%2BD1MXktV2gtrY%3D 19330284
HG Martinez del M Lopez-Bravo P Metharom C Ardavin P Aucouturier 2006 Prion protein expression by mouse dendritic cells is restricted to the nonplasmacytoid subsets and correlates with the maturation state J Immunol 177 6137 6142
DA Mitchell L Kirby SM Paulin CL Villiers RB Sim 2007 Prion protein activates and fixes complement directly via the classical pathway: implications for the mechanism of scrapie agent propagation in lymphoid tissue Mol Immunol 44 2997 3004 10.1016/j.molimm.2006.12.027 1:CAS:528:DC%2BD2sXjtVWrtL4%3D 17337056 (Pubitemid 46412484)
D Nielsen H Gyllberg P Ostlund T Bergman K Bedecs 2004 Increased levels of insulin and insulin-like growth factor-1 hybrid receptors and decreased glycosylation of the insulin receptor alpha- and beta-subunits in scrapie-infected neuroblastoma N2a cells Biochem J 380 571 579 10.1042/BJ20040010 1:CAS:528:DC%2BD2cXksFyhs78%3D 15025560 (Pubitemid 38788129)
D Nikles K Vana S Gauczynski H Knetsch H Ludewigs S Weiss 2008 Subcellular localization of prion proteins and the 37 kDa/67 kDa laminin receptor fused to fluorescent proteins Biochim Biophys Acta 1782 335 340 1:CAS:528:DC%2BD1cXlsFyjurg%3D 18339329
P Pasquali, et al. 2006 Intracerebral administration of interleukin-12 (IL-12) and IL-18 modifies the course of mouse scrapie BMC Vet Res 2 37 10.1186/1746-6148-2-37 17192191 (Pubitemid 46178353)
F Pimpinelli S Lehmann I Maridonneau-Parini 2005 The scrapie prion protein is present in flotillin-1-positive vesicles in central- but not peripheral-derived neuronal cell lines Eur J Neurosci 21 2063 2072 10.1111/j.1460-9568.2005.04049.x 15869502 (Pubitemid 40695230)
J Priller M Prinz M Heikenwalder N Zeller P Schwarz FL Heppner A Aguzzi 2006 Early and rapid engraftment of bone marrow-derived microglia in scrapie J Neurosci 26 11753 11762 10.1523/JNEUROSCI.2275-06.2006 1:CAS:528: DC%2BD28Xht1Glu7jO 17093096 (Pubitemid 44772146)
CR Raymond P Aucouturier NA Mabbott 2007 In vivo depletion of CD11c+ cells impairs scrapie agent neuroinvasion from the intestine J Immunol 179 7758 7766 1:CAS:528:DC%2BD2sXhtlajt7jP 18025222
P Rezaie PL Lantos 2001 Microglia and the pathogenesis of spongiform encephalopathies Brain Res Brain Res Rev 35 55 72 10.1016/S0165-0173(01)00042-X 1:CAS:528:DC%2BD3MXhs1eitLY%3D 11245886 (Pubitemid 32201876)
A Rustom R Saffrich I Markovic P Walther HH Gerdes 2004 Nanotubular highways for intercellular organelle transport Science 303 1007 1010 10.1126/science.1093133 1:CAS:528:DC%2BD2cXhtlWnu7w%3D 14963329 (Pubitemid 38209703)
C Rybner-Barnier, et al. 2006 Processing of the bovine spongiform encephalopathy-specific prion protein by dendritic cells J Virol 80 4656 4663 10.1128/JVI.80.10.4656-4663.2006 1:CAS:528:DC%2BD28XkslChtrs%3D 16641258
D Sarnataro A Caputo P Casanova C Puri S Paladino SS Tivodar V Campana C Tacchetti C Zurzolo 2009 Lipid rafts and clathrin cooperate in the internalization of PrP in epithelial FRT cells PLoS One 4 e5829 10.1371/journal.pone.0005829 19503793
CJ Sigurdson TR Spraker MW Miller B Oesch EA Hoover 2001 PrP(CWD) in the myenteric plexus, vagosympathetic trunk and endocrine glands of deer with chronic wasting disease J Gen Virol 82 2327 2334 1:CAS:528:DC%2BD3MXnsFOis7w%3D 11562526
van Keulen LJ, Schreuder BE, Vromans ME, Langeveld JP, Smits MA (2000) Pathogenesis of natural scrapie in sheep. Arch Virol Suppl (16):57-71
LJ van Keulen ME Vromans FG van Zijderveld 2002 Early and late pathogenesis of natural scrapie infection in sheep APMIS 110 23 32 10.1034/j.1600-0463.2002.100104.x 12064252 (Pubitemid 34289466)
K Wakasugi T Nakano C Kitatsuji I Morishima 2004 Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein Biochem Biophys Res Commun 318 453 460 10.1016/j.bbrc.2004.04.045 1:CAS:528: DC%2BD2cXjs1Cjs7w%3D 15120622 (Pubitemid 38553801)