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Etude complémentaire de la cytotoxicite de la mélinonine F, alcaloide dérive de la beta-carboline
Bassleer, Roger; Marnette, J. M.; Wiliquet, P. et al.
1983 • In Planta Medica, 49 (11), p. 158-161
Peer Reviewed verified by ORBi
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https://hdl.handle.net/2268/37275
DOI
10.1055/s-2007-969838
PubMed
6657787
 

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Keywords :
Strychnos melinoniana; Strychnos usambarensis; melinonine F; cancer cells; DNA intercalation
Abstract :
[en] The cellular effects of melinonine F, an alkaloid isolated from STRYCHNOS MELINONIANA (South America) and STRYCHNOS USAMBARENSIS (Central Africa), are analysed in cancer or normal cells in culture. A cytotoxic action is noted in both types of cells, at least for relatively high concentrations. These effects are probably due to interaction of the drug with chromatin. Physico-chemical analysis demonstrates partial intercalation of melinonine F on pure DNA IN VITRO.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Bassleer, Roger ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Marnette, J. M.
Wiliquet, P.
De Pauw-Gillet, Marie-Claire ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques
Caprasse, M.
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
French
Title :
Etude complémentaire de la cytotoxicite de la mélinonine F, alcaloide dérive de la beta-carboline
Alternative titles :
[en] Complementary Study of Cytotoxic Activity of Melinonine F.
Publication date :
November 1983
Journal title :
Planta Medica
ISSN :
0032-0943
eISSN :
1439-0221
Publisher :
Georg Thieme Verlag, Germany
Volume :
49
Issue :
11
Pages :
158-161
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 May 2010

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