Strychnos melinoniana; Strychnos usambarensis; melinonine F; cancer cells; DNA intercalation
Abstract :
[en] The cellular effects of melinonine F, an alkaloid isolated from STRYCHNOS MELINONIANA (South America) and STRYCHNOS USAMBARENSIS (Central Africa), are analysed in cancer or normal cells in culture. A cytotoxic action is noted in both types of cells, at least for relatively high concentrations. These effects are probably due to interaction of the drug with chromatin. Physico-chemical analysis demonstrates partial intercalation of melinonine F on pure DNA IN VITRO.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Bassleer, Roger ; Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Marnette, J. M.
Wiliquet, P.
De Pauw-Gillet, Marie-Claire ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques
Caprasse, M.
Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
French
Title :
Etude complémentaire de la cytotoxicite de la mélinonine F, alcaloide dérive de la beta-carboline
Alternative titles :
[en] Complementary Study of Cytotoxic Activity of Melinonine F.
