Reference : Lanreotide Autogel for acromegaly: a new addition to the treatment armamentarium.
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Lanreotide Autogel for acromegaly: a new addition to the treatment armamentarium.
Ciccarelli, Antonio [> > > >]
Daly, Adrian [Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie >]
Beckers, Albert mailto [Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie >]
Treatments in Endocrinology
Adis International
Yes (verified by ORBi)
[en] Acromegaly/blood/drug therapy ; Gels ; Human Growth Hormone/blood ; Humans ; Injections, Subcutaneous ; Insulin-Like Growth Factor I/analysis ; Peptides, Cyclic/administration & dosage/pharmacokinetics/pharmacology ; Somatostatin/administration & dosage/analogs & derivatives/pharmacokinetics/pharmacology
[en] Since their introduction into clinical practice, somatostatin analogs have been the pharmacological therapy of choice for the treatment of acromegaly. The first preparations of somatostatin analogs available for clinical use were administered subcutaneously two or three times daily, which was not optimal with respect to patient compliance. The introduction of long-acting formulations of somatostatin analogs has overcome this inconvenience. Lanreotide Autogel, a new viscous, supersaturated, aqueous solution of lanreotide, is available in a prefilled syringe and administered by deep subcutaneous injection every 28 days. Lanreotide Autogel has different pharmacokinetic properties from the earlier lanreotide slow-release (SR) formulation, which may account for its better tolerability. Furthermore, lanreotide Autogel is at least as efficacious as the other somatostatin analogs in lowering growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels in the majority and in restoring safe GH and age-normalized IGF-1 levels in about 50-60% of patients with acromegaly. In conclusion, lanreotide Autogel is a valuable new addition to the acromegaly treatment armamentarium. Patients receiving intramuscular lanreotide SR injections every 7-14 days can be switched to an appropriate dose of deep subcutaneous lanreotide Autogel every 28 days, without any impact on safety or loss of efficacy.
Researchers ; Professionals

File(s) associated to this reference

Fulltext file(s):

Restricted access
Lanréotide AUtogel for Acromegaly.pdfPublisher postprint693.36 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.