Regulation of cancer invasion and vascularization by plasminogen activator inhibitor-1

[en] Acquisition of invasive/metastatic potential through protease expression is a key event in tumor progression. The proteolytic enzyme plasmin is generated from the precursor plasminogen by the action of urokinase-type plasminogen activator (urokinase, uPA) or tissue-type plasminogen activator (tPA). Plasminogen activator inhibitor-1 or PAI-1 is the main inhibitor of uPA and tPA. High levels of components of this proteolytic system, including uPA and its cell surface receptor (uPAR), have been correlated with a poor prognosis for different cancers. It was therefore anticipated that PAI-1 expression would be associated with favorable outcome. Paradoxically, high rather than low PAI-1 levels predict poor survival of patients suffering from a variety of cancers. Recent observations indicate a much more complex role of PAI-1 in tumor progression and angiogenesis than initially expected. The exact mechanisms of this multifunctional molecule remain puzzling.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Noël, Agnès ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme

Bajou, Khalid ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire

Masson, Véronique ; Université de Liège - ULiège > Gynécologie-Obstétrique CHR

Frankenne, F.

Rakic, Jean-Marie ; Université de Liège - ULiège > Département des sciences cliniques > Ophtalmologie

Lambert, Vincent ; Université de Liège - ULiège > Ophtalmologie

Carmeliet, P.

Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement

Language :

English

Title :

Regulation of cancer invasion and vascularization by plasminogen activator inhibitor-1

Publication date :

1999

Journal title :

Fibrinolysis and Proteolysis

ISSN :

1369-0191

Publisher :

Harcourt Publishers Ltd

Volume :

Issue :

Pages :

220-225

Peer reviewed :

Peer reviewed

Available on ORBi :

since 18 May 2010

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