Mass spectrometry imaging; MALDI; TOF-SIMS; Lipids; rat brain
Abstract :
[en] Mass spectrometry imaging is becoming a more
and more widely used method for chemical mapping of
organic and inorganic compounds from various surfaces,
especially tissue sections. Two main different techniques are
now available: matrix-assisted laser desorption/ionizaton,
where the sample, preliminary coated by an organic matrix,
is analyzed by a UV laser beam; and secondary ion mass
spectrometry, for which the target is directly submitted to a
focused ion beam. Both techniques revealed excellent
performances for lipid mapping of tissue surfaces. This
article will discuss similarities, differences, and specificities
of ion images generated by these two techniques in terms of
sample preparation, sensitivity, ultimate spatial resolution,
and structural analysis.
Disciplines :
Chemistry
Author, co-author :
Benabdellah, Farida; Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France
Seyer, Alexandre; Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France
Quinton, Loïc ; Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)
Touboul, David; Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France
Brunelle, Alain; Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France
Laprévote, Olivier; Centre National de la Recherche Scientifique - CNRS > Institut de Chimie des Substances Naturelles - Laboratoire de spectrométrie de Masse- 91198 Gif-sur-Yvette Cedex, France
Language :
English
Title :
Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus nanometer resolution by TOF–SIMS
Publication date :
January 2010
Journal title :
Analytical and Bioanalytical Chemistry
ISSN :
1618-2642
eISSN :
1618-2650
Publisher :
Springer Science & Business Media B.V., Berlin, Germany
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