Article (Scientific journals)
Matadine, a cytotoxic alkaloid from Strychnos gossweileri
Quetin-Leclercq, Joëlle; Coucke, Paul; Delaude, Clément et al.
1991In Phytochemistry, 30 (5), p. 1697-1700
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Keywords :
Strychnos gossweileri; indole alkaloid; matadine; 2D NMR spectra; anhydronium base
Abstract :
[en] Matadine, a new alkaloid, has been isolated from the root bark of Strychnos gossweileri. Elucidation of its structure is mainly based on 1H and 1D NMR studies. Its cytotoxic activity has been tested on cancer cells and normal cells. Matadine is an anhydronium base as serpentine, that exerts also a selective inhibiting activity on B16 melanoma cells while it is less toxic in human 2002 non-cancer cells. This selective activity might be well due , as it seems to be the case for serpentine and alstonine, to a higher affinity of matadine for destabilized single-stranded DNA as mainly present in cancer cells.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Quetin-Leclercq, Joëlle
Coucke, Paul ;  Université de Liège - ULiège
Delaude, Clément ;  Université de Liège - ULiège > Relations académiques et scientifiques (Sciences)
Warin, Roger ;  Université de Liège - ULiège > Département de géologie > Minéralogie et cristallochimie
Bassleer, Roger ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Matadine, a cytotoxic alkaloid from Strychnos gossweileri
Publication date :
1991
Journal title :
Phytochemistry
ISSN :
0031-9422
eISSN :
1873-3700
Publisher :
Pergamon Press, New York, United States - New York
Volume :
30
Issue :
5
Pages :
1697-1700
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 May 2010

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