Strychnos henningsii; indole alkaloids; (iso)-retuline; antinociceptive properties; therapeutic index
Abstract :
[en] Strychnos henningsii GILG is used in African traditional medicine for the treatment of various ailments, including rheumatism, gastrointestinal complaints, malaria and snake bites. Different preliminary pharmacological experiments are described. The results show that some of the reported folk medicinal applications of S. henningsii can be at least partially explained by the presence of retuline-like alkaloids, whose use could lead to new antinociceptive (antiinflammatory and analgesic) and antispasmodic drugs.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Tits, Monique ; Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Damas, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Quetin-Leclercq, Joëlle
Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
From ethnobotanical uses of Strychnos henningsii to antiinflammatories, analgesics and antispasmodics
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