Reference : Prognostic factors in patients with Zollinger-Ellison syndrome and multiple endocrine...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/36428
Prognostic factors in patients with Zollinger-Ellison syndrome and multiple endocrine neoplasia type 1. Groupe d'Etude des Neoplasies Endocriniennes Multiples (GENEM and groupe de Recherche et d'Etude du Syndrome de Zollinger-Ellison (GRESZE).
English
Cadiot, G. [> > > >]
Vuagnat, A. [> > > >]
Doukhan, I. [> > > >]
Murat, A. [> > > >]
Bonnaud, G. [> > > >]
Delemer, B. [> > > >]
Thiefin, G. [> > > >]
Beckers, Albert mailto [Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie >]
Veyrac, M. [> > > >]
Proye, C. [> > > >]
Ruszniewski, P. [> > > >]
Mignon, M. [> > > >]
Feb-1999
Gastroenterology
W.B. Saunders
116
2
286-293
Yes (verified by ORBi)
International
0016-5085
1528-0012
Philadelphia
PA
[en] Adult ; Aged ; Female ; Humans ; Liver Neoplasms/secondary ; Male ; Medical Records ; Middle Aged ; Multiple Endocrine Neoplasia Type 1/diagnosis ; Multivariate Analysis ; Neoplasms, Second Primary/diagnosis ; Odds Ratio ; Pancreatic Neoplasms/pathology ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival Analysis ; Zollinger-Ellison Syndrome/diagnosis
[en] BACKGROUND & AIMS: Risk factors of metachronous liver metastases and death are not well known in patients with the Zollinger-Ellison syndrome and multiple endocrine neoplasia type 1. These factors were retrospectively determined in 77 patients. METHODS: Data chart review was performed. RESULTS: Median follow-up was 102 months (range, 12-366). Surgery was performed on 48 patients, including 9 of the 10 patients with large pancreatic tumors (>/=3 cm). Liver metastases developed in 4 patients (40%) with large pancreatic tumors, in 3 (4.8%) without, and in 1 of the 4 patients with pancreatic tumors of unknown size; all had previously undergone surgery. The only independent factor associated with development of liver metastases identified by multivariate analysis was large pancreatic tumors (risk ratio, 29.0; 95% confidence interval [CI], 3. 2-260.7). Surgery was not selected. The probability of being free of liver metastases in the 63 patients without large pancreatic tumors was 96% (95% CI, 88-100) at 10 and 15 years. Thirteen (16.9%) patients died. The only independent factors of death selected by multivariate analysis were Zollinger-Ellison syndrome diagnosis before 1980 (risk ratio, 8.2; 95% CI, 1.7-40.6) and age at diagnosis (risk ratio/year, 1.08; 95% CI, 1.03-1.14). CONCLUSIONS: Large pancreatic tumors are predictive of the development of metachronous liver metastases, and surgery does not seem to prevent them.
Researchers ; Professionals
http://hdl.handle.net/2268/36428
10.1016/S0016-5085(99)70124-1

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