Article (Scientific journals)
Investigation of singlet oxygen reactivity towards propofol
Heyne, Belinda; Kohnen, Stephan; Brault, Daniel et al.
2003In Photochemical and Photobiological Sciences, 2 (9), p. 939-945
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Keywords :
propofol; spectroscopy; singlet oxygen
Abstract :
[en] The reaction between the anaesthetic agent 2,6-diisopropylphenol (propofol, PPF) and singlet oxygen (1O2) has been investigated in aqueous solution by means of HPLC, GC, absorption spectroscopy and laser flash photolysis with infrared luminescence detection. The rate constants for the physical and chemical quenching of 1O2 by PPF (kPPF) are found to be 2.66 x 10(5) M(-1) s(-1) and approximately 3.2 x 10(6) M(-1) s(-1) in CD3OD and D2O-CD3OD (75:25 v/v), respectively. The reaction of propofol with singlet oxygen produced by light irradiation of Rose Bengal leads essentially to two reaction products, 2,6-diisopropyl-p-benzoquinone and 3,5,3',5'-tetraisopropyl-(4,4')-diphenoquinone that are unambiguously identified from comparison with authentic samples.
Disciplines :
Physics
Biochemistry, biophysics & molecular biology
Author, co-author :
Heyne, Belinda
Kohnen, Stephan ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Brault, Daniel
Mouithys-Mickalad, Ange ;  Université de Liège - ULiège > Centre de l'oxygène : Recherche et développement (C.O.R.D.)
Tfibel, Francis
Hans, Pol ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Fontaine-Aupart, Marie-Pierre
Hoebeke, Maryse  ;  Université de Liège - ULiège > Département de physique > Spectroscopie biomédicale
Language :
English
Title :
Investigation of singlet oxygen reactivity towards propofol
Publication date :
September 2003
Journal title :
Photochemical and Photobiological Sciences
ISSN :
1474-905X
eISSN :
1474-9092
Publisher :
Royal Soc Chemistry, Cambridge, United Kingdom
Volume :
2
Issue :
9
Pages :
939-945
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 May 2010

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