Investigation of singlet oxygen reactivity towards propofol

[en] The reaction between the anaesthetic agent 2,6-diisopropylphenol (propofol, PPF) and singlet oxygen (1O2) has been investigated in aqueous solution by means of HPLC, GC, absorption spectroscopy and laser flash photolysis with infrared luminescence detection. The rate constants for the physical and chemical quenching of 1O2 by PPF (kPPF) are found to be 2.66 x 10(5) M(-1) s(-1) and approximately 3.2 x 10(6) M(-1) s(-1) in CD3OD and D2O-CD3OD (75:25 v/v), respectively. The reaction of propofol with singlet oxygen produced by light irradiation of Rose Bengal leads essentially to two reaction products, 2,6-diisopropyl-p-benzoquinone and 3,5,3',5'-tetraisopropyl-(4,4')-diphenoquinone that are unambiguously identified from comparison with authentic samples.

Disciplines :

Physics
Biochemistry, biophysics & molecular biology

Author, co-author :

Heyne, Belinda

Kohnen, Stephan ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux

Brault, Daniel

Mouithys-Mickalad, Ange ; Université de Liège - ULiège > Centre de l'oxygène : Recherche et développement (C.O.R.D.)

Tfibel, Francis

Hans, Pol ; Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation

Fontaine-Aupart, Marie-Pierre

Hoebeke, Maryse ; Université de Liège - ULiège > Département de physique > Spectroscopie biomédicale

Language :

English

Title :

Investigation of singlet oxygen reactivity towards propofol

Publication date :

September 2003

Journal title :

Photochemical and Photobiological Sciences

ISSN :

1474-905X

eISSN :

1474-9092

Publisher :

Royal Soc Chemistry, Cambridge, United Kingdom

Volume :

Issue :

Pages :

939-945

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 13 May 2010

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