Article (Scientific journals)
Photochemistry of 2,6-diisopropylphenol (propofol)
Heyne, B.; Tfibel, F.; Hoebeke, Maryse et al.
2006In Photochemical and Photobiological Sciences, 5 (11), p. 1059-1067
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Keywords :
propofol; laser flash photolysis
Abstract :
[en] The photochemistry of the anaesthetic agent propofol (PPF) was investigated in three different solvents of quite different polarity (cyclohexane, methanol and phosphate buffer pH 7) by means of nanosecond laser flash photolysis and absorption spectroscopy. GC-MS spectrometry measurements of PPF in cyclohexane have revealed the formation of two major products upon low intensity UV continuous irradiation of PPF in aerated solution: the diphenol derivative of PPF and 2,6-diisopropyl-p-benzoquinone (PPFQ). Only the diphenol compound was obtained in anaerobic solution. PPF phenoxyl radical (PPF ) generation has been assigned as the original step leading to the formation of both the diphenol compound and PPFQ in cyclohexane as revealed by laser flash photolysis at 266 nm and by electron paramagnetic resonance spectroscopy as well. Investigation of PPF by nanosecond flash photolysis at 266 nm in the other solvents revealed the occurrence of different photochemical processes depending on the nature and the polarity of the solvent. A reaction scheme is proposed in order to discuss the mechanism of reaction of PPF in all media.
Disciplines :
Biochemistry, biophysics & molecular biology
Physics
Author, co-author :
Heyne, B.
Tfibel, F.
Hoebeke, Maryse  ;  Université de Liège - ULiège > Département de physique > Spectroscopie biomédicale
Hans, Pol ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Maurel, V.
Fontaine-Aupart, Marie-Pierre
Language :
English
Title :
Photochemistry of 2,6-diisopropylphenol (propofol)
Publication date :
November 2006
Journal title :
Photochemical and Photobiological Sciences
ISSN :
1474-905X
eISSN :
1474-9092
Publisher :
Royal Soc Chemistry, Cambridge, United Kingdom
Volume :
5
Issue :
11
Pages :
1059-1067
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 May 2010

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