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Peroxidase-Catalysed Oxidation of Different Dibenzazepine Derivatives
Liégeois, Jean-François; Rogister, F.; Delarge, J. et al.
1995In Archiv der Pharmazie, 328 (2), p. 109-12
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Abstract :
[en] According to a recent hypothesis suggesting the potential role of free radical formation in the clozapine-induced agranulocytosis, we have evaluated the susceptibility to the peroxidase-mediated oxidation of different dibenzazepine analogues. On the one hand, compounds with an arylamine group such as clozapine or isoclozapine present a high reactivity in the horseradish peroxidase or myeloperoxidase systems and, on the other hand, fluperlapine, though known to induce agranulocytosis, and other dibenzothiazepine and dibenzoxazepine derivatives appear insensitive to oxidation. Consequently, among tricyclic derivatives, the way of diaryloxa- and diarylthiazepine compounds could be an alternative for the development of safer drugs such as antipsychotics.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Liégeois, Jean-François ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Rogister, F.
Delarge, J.
Pincemail, Joël ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire
Language :
English
Title :
Peroxidase-Catalysed Oxidation of Different Dibenzazepine Derivatives
Publication date :
February 1995
Journal title :
Archiv der Pharmazie
ISSN :
0365-6233
eISSN :
1521-4184
Publisher :
John Wiley & Sons, United Kingdom
Volume :
328
Issue :
2
Pages :
109-12
Peer reviewed :
Peer reviewed
Available on ORBi :
since 11 January 2010

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