Reference : Calretinin expression as a critical component in the control of dentate gyrus long-te...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Life sciences : Genetics & genetic processes
Calretinin expression as a critical component in the control of dentate gyrus long-term potentiation in mice
Gurden, H. [Rhône-Poulenc Rorer S.A., Vitry-sur-Seine, France > > > >]
Schiffmann, S. N. [Université Libre de Bruxelles - ULB > > > >]
Lemaire, M. [Rhône-Poulenc Rorer S.A., Vitry-sur-Seine, France > > > >]
Böhme, G. A. [Rhône-Poulenc Rorer S.A., Vitry-sur-Seine, France > > > >]
ParmentieR, M. [Université Libre de Bruxelles - ULB > > > >]
Schurmans, Stéphane mailto [Université Libre de Bruxelles - ULB > Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Institut de Biologie et de Médecine Moléculaire > > >]
European Journal of Neuroscience
Blackwell Science
Yes (verified by ORBi)
[en] calcium ; calcium binding proteins ; hippocampus ; mossy cells ; synaptic plasticity
[en] We have recently reported that mice homozygous (Cr–/–) for a null mutation in the calretinin gene have impaired long‐term potentiation (LTP) induction in the dentate gyrus (S. Schurmans et al. (1997) Proc. Natl. Acad. Sci. USA, 94, 10415 ). Here, we investigated dentate LTP induction in mice heterozygous (Cr+/–) for the same mutation. Despite the presence of calretinin in neurons of these mice, although at reduced levels as compared with normal mice, LTP induction in dentate gyrus was totally impaired. Spatial memory and learning were found unaffected in Cr+/– mice, such as in Cr–/– mice. Altogether, our results suggest that calretinin is a critical component in the control of dentate synaptic plasticity in mice, and that levels of calretinin higher than those observed in Cr+/– mice are required to induce LTP in this area. The possible mechanisms leading to the absence of correlation between gene dosage and biological effects are discussed
Researchers ; Professionals

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