[en] We have recently reported that mice homozygous (Cr–/–) for a null mutation in the calretinin gene have impaired long‐term potentiation (LTP) induction in the dentate gyrus (S. Schurmans et al. (1997) Proc. Natl. Acad. Sci. USA, 94, 10415 ). Here, we investigated dentate LTP induction in mice heterozygous (Cr+/–) for the same mutation. Despite the presence of calretinin in neurons of these mice, although at reduced levels as compared with normal mice, LTP induction in dentate gyrus was totally impaired. Spatial memory and learning were found unaffected in Cr+/– mice, such as in Cr–/– mice. Altogether, our results suggest that calretinin is a critical component in the control of dentate synaptic plasticity in mice, and that levels of calretinin higher than those observed in Cr+/– mice are required to induce LTP in this area. The possible mechanisms leading to the absence of correlation between gene dosage and biological effects are discussed
Gurden, H.; Rhône-Poulenc Rorer S.A., Vitry-sur-Seine, France
Schiffmann, S. N.; Université Libre de Bruxelles - ULB
Lemaire, M.; Rhône-Poulenc Rorer S.A., Vitry-sur-Seine, France
Böhme, G. A.; Rhône-Poulenc Rorer S.A., Vitry-sur-Seine, France
ParmentieR, M.; Université Libre de Bruxelles - ULB
Schurmans, Stéphane ; Université Libre de Bruxelles - ULB > Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Institut de Biologie et de Médecine Moléculaire
Language :
English
Title :
Calretinin expression as a critical component in the control of dentate gyrus long-term potentiation in mice
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