Sendai virus-induced alterations in lung structure/function correlate with viral loads and reveal a wide resistance/susceptibility spectrum among mouse strains
Faisca, Pedro; Bui Tran Anh, Dao; Desmecht, Daniel
2005 • In American Journal of Physiology - Lung Cellular and Molecular Physiology, 289, p. 777-787
[en] The Paramyxoviridae family includes some of the most important and ubiquitous disease-causing viruses of infants and children, most of which cause significant infections of the respiratory tract. Evidence is accumulating in humans that genetic factors are involved in the severity of clinical presentation. As a first step toward the identification of the genes involved, this study was undertaken to establish whether laboratory mouse strains differ in susceptibility to Sendai virus, the murine counterpart of human type-1 parainfluenza virus which, historically, has been used extensively in studies that have defined the basic biological properties of paramyxoviruses in general. With this purpose in mind, double-chamber plethysmography data were collected daily for 7 days after inoculation of Sendai virus in six inbred strains of mice. In parallel, histological examinations and lung viral titration were carried out from day 5 to day 7 after inoculation. Pulmonary structure/function values closely reflected the success of viral replication in the lungs and revealed a pattern of continuous variation with resistant, intermediate, and susceptible strains. The results unambiguously suggest that BALB/c (resistant) and 129Sv (susceptible) strains should be used in crossing experiments aimed at identifying the genes involved in resistance to Paramyxoviridae by the positional cloning approach.
Disciplines :
Immunology & infectious disease
Author, co-author :
Faisca, Pedro; Université de Liège - ULiège > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies
Bui Tran Anh, Dao; Université de Liège - ULiège > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies
Desmecht, Daniel ; Université de Liège - ULiège > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies
Language :
English
Title :
Sendai virus-induced alterations in lung structure/function correlate with viral loads and reveal a wide resistance/susceptibility spectrum among mouse strains
Publication date :
2005
Journal title :
American Journal of Physiology - Lung Cellular and Molecular Physiology
ISSN :
1040-0605
eISSN :
1522-1504
Publisher :
American Physiological Society, Bethesda, United States - Maryland
Abel L, Demenais F, Prata A, Souza AE, and Dessein A. Evidence for the segregation of a major gene in human susceptibility/resistance to infection by Shistosoma mansoni. Am J Hum Genet 48: 959-970, 1991.
Abel L, Vu DL, Oberti J, Nguyen VT, Van VC, Guilloud-Bataille M, Schurr E, and Lagrange PH. Complex segregation analysis of leprosy in southern Vietnam. Genet Epidemiol 12: 63-82, 1995.
Alarie Y. Computer-based bioassay for evaluation of sensory irritation of airborne chemicals and its limit of detection. Arch Toxicol 72: 277-282, 1998.
Alcais A, Abel L, David C, Torrez ME, Flandre P, and Dedet JP. Evidence for a major gene controlling susceptibility to tegumentary leishmaniasis in a recently exposed Bolivian population. Am J Hum Genet 61: 968-979, 1997.
Appel LH, Kovatch RM, Reddecliff JM, and Gerone PJ. Pathogenesis of Sendai virus infection in mice. Am J Vet Res 32: 1835-1841, 1971.
Atchley WR and Fitch WM. Gene trees and the origins of inbred strains of mice. Science 254: 554-558, 1991.
Blandford G, Curenton RJ, and Heath RB. Studies on the immune response in Sendai virus infection of mice. J Med Microbiol 4: 351-354, 1971.
Boylstein LA, Anderson SJ, Thompson RD, and Alarie Y. Characterization of the effects of an airborne mixture of chemicals on the respiratory tract smoothing polynomial spline analyses of the data. Arch Toxicol 69: 579-589, 1995.
Breider MA, Adams LG, and Womack JE. Influence of interferon in natural resistance of mice to Sendai virus pneumonia. Am J Vet Res 48: 1746-1750, 1987.
Brown MG, Scalzo AA, Matsumoto K, and Yokoyama WM. The natural killer gene complex: a genetic basis for understanding natural killer cell function and innate immunity. Immunol Rev 155: 53-65, 1997.
Brownstein DG. Genetics of natural resistance to Sendai virus infection in mice. Infect Immun 41: 308-312, 1983.
Brownstein DG and Gras L. Chromosome mapping of Rmp-4, a gonad-dependent gene encoding host resistance to mousepox. J Virol 69: 6958-6964, 1995.
Brownstein DG, Smith AL, and Johnson EA. Sendai virus infection in genetically resistant and susceptible mice. Am J Pathol 105: 156-163, 1981.
Brownstein DG and Winkler S. Genetic resistance to lethal Sendai virus pneumonia: virus replication and interferon production in C57BL/6J and DBA/2J mice. Lab Anim Sci 36: 126-129, 1986.
Brownstein DG and Winkler S. Genetic determinants of lung virus titers and resistance to lethal Sendai virus pneumonia. Arch Virol 96: 201-214, 1987.
Chanock RM, Murphy BR, and Collins PL. Parainfluenza viruses. In: Fields Virology, edited by Fields BN, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, Straus SE, and Knipe DM. Philadelphia, PA: Lippincott Williams & Wilkins, 2001.
De Sanctis GT, Jiao A, Lee YH, Haynes TC, Lander ES, Beier DR, and Drazen JM. Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice. Am J Physiol Lung Cell Mol Physiol 277: L1118-L1123, 1999.
Farre R, Rotger M, Montserrat JM, Calero G, and Navajas D. Collapsible upper airway segment to study obstructive sleep apnea/hypopnea syndrome in rats. Respir Physiol Neurobiol 136: 199-209, 2003.
Flandre TD, Leroy PL, and Desmecht DJ. Effect of somatic growth, strain, and sex on double-chamber plethysmography respiratory function values in healthy mice. J Appl Physiol 94: 1129-1136, 2003.
Garcia A, Abel L, Cot M, Richard P, Ranque S, Feingold J, Demenais F, Boussinesq M, and Chippaux JP. Genetic epidemiology of host predisposition microfilaraemia in human loiasis. Trop Med Int Health 4: 565-574, 1999.
Green MC. Catalog of mutant genes and polymorphic loci. In: Genetic Variants and Strains of the Laboratory Mouse, edited by Green MC. Stuttgart, Germany: Gustav Fischer, 1989.
Held HD and Uhlig S. Basal lung mechanics and airway and pulmonary vascular responsiveness in different inbred mouse strains. J Appl Physiol 88: 2192-2198, 2000.
Itoh T, Iwai H, and Ueda K. Comparative lung pathology of inbred strains of mice resistant and susceptible to Sendai virus infection. J Vet Med Sci 53: 275-279, 1991.
Jin HK, Takada A, Kon Y, Haller O, and Watanabe T. Identification of the murine Mx2 gene: interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus. J Virol 73: 4925-4930, 1999.
Jin HK, Yoshimatsu K, Takada A, Ogino M, Asano A, Arikawa J, and Watanabe T. Mouse Mx2 protein inhibits hantavirus but not influenza virus replication. Arch Virol 146: 41-49, 2001.
Martinson JJ, Chapman NH, Rees DC, Liu YT, and Clegg JB. Global distribution of the CCR5 gene 32-basepair deletion. Nat Genet 16: 100-103, 1997.
Morris JB, Symanowicz PT, Olsen JE, Thrall RS, Cloutier MM, and Hubbard AK. Immediate sensory nerve-mediated respiratory responses to irritants in healthy and allergic airway-diseased mice. J Appl Physiol 94: 1563-1571, 2003.
Morris JB, Wilkie WS, and Shusterman DJ. Acute respiratory responses of the mouse to chlorine. Toxicol Sci 83: 380-387, 2005.
Nielsen GD, Hougaard KS, Larsen ST, Hammer M, Wolkoff P, Clausen PA, Wilkins CK, and Alarie Y. Acute airway effects of formaldehyde and ozone in BALB/c mice. Hum Exp Toxicol 18: 400-409, 1999.
Ohtsuka N and Taguchi F. Mouse susceptibility to mouse hepatitis virus infection is linked to viral receptor genotype. J Virol 71: 8860-8863, 1997.
Pennock BE, Cox CP, Rogers RM, Cain A, and Wells J. A noninvasive technique for measurement of changes in specific airway resistance. J Appl Physiol 46: 399-406, 1979.
Plancoulaine S, Gessain A, Joubert M, Tortevoye P, Jeanne I, Talarmin A, de The G, and Abel L. Detection of a major gene predisposing to human T lymphotropic virus type I infection in children among an endemic population of African origin. J Infect Dis 182: 405-412, 2000.
Plancoulaine S, Gessain A, van Beveren M, Tortevoye P, and Abel L. Evidence for a recessive major gene predisposing to human herpesvirus 8 (HVH-8) infection in a population in which HHV-8 is endemic. J Infect Dis 187: 1944-1950, 2003.
Reinhard C, Eder G, Fuchs H, Ziesenis A, Heyder J, and Schulz H. Inbred strain variation in lung function. Mamm Genome 13: 429-437, 2002.
Robinson TW, Curenton RJ, and Heath RB. The pathogenesis of Sendai virus infection in the mouse lung. J Med Microbiol 1: 89-95, 1968.
Schaper M and Brost MA. Respiratory effects of trimellitic anhydride aerosols in mice. Arch Toxicol 65: 671-677, 1991.
Schulz H, Johner C, Eder G, Ziesenis A, Reitmeier P, Heyder J, and Balling R. Respiratory mechanics in mice: strain and sex specific differences. Acta Physiol Scand 174: 367-375, 2002.
Shaw MA, Davies CR, Llanos-Cuentas EA, and Collins A. Human genetic susceptibility and infection with Leishmania peruviana. Am J Hum Genet 57: 1159-1168, 1995.
Staeheli P, Gob R, Meier E, Sutcliffe JG, and Haller O. Influenza virus-susceptibility mice carry Mx genes with a large deletion or a nonsense mutation. Mol Cell Biol 8: 4518-4523, 1988.
Sugita K, Maru M, and Sato K. Biological properties of plaque-size variants of Sendai virus. Microbiol Immunol 25: 353-360, 1981.
Tankersley CG, Rabold R, and Mitzner W. Differential lung mechanics are genetically determined in inbred murine strains. J Appl Physiol 86: 1764-1769, 1999.
Tashiro M, Yokogoshi Y, Tobita K, Seto J, Rott R, and Kido H. Tryptase Clara, an activating protease for Sendai virus in rat lungs, is involved in pneumopathogenicity. J Virol 66: 7211-7216, 1992.
Vijayaraghavan R, Schaper M, Thompson R, Stock MF, and Alarie Y. Characteristic modifications of the breathing pattern of mice to evaluate the effects of airborne chemicals on the respiratory tract. Arch Toxicol 67: 478-490, 1993.
Yamaguchi R, Iwai H, and Ueda K. Variation of virulence and other properties among Sendai virus strains. Microbiol Immunol 32: 235-240, 1988.
