Analyzing Bunyaviruses from a One Health Perspective

Zoonotic viral diseases continue to pose major challenges to global health, particularly as environmental, social and economic changes increasingly influence interactions among humans, animals, vectors, and ecosystems. This review explores Rift Valley fever virus (RVFV), Crimean-Congo hemorrhagic fever virus (CCHFV), and hantaviruses (HTVs) within the framework of One Health, emphasizing the ecological and epidemiological factors that govern their emergence and transmission. Despite their distinct transmission cycles, these viruses share important determinants of zoonotic risk. RVFV is primarily maintained through interactions between mosquitoes, livestock, wildlife, and humans; CCHFV is sustained within complex tick–vertebrate systems involving Hyalomma ticks, domestic animals, and wildlife, while HTVs are predominantly maintained through persistent infections in mammalian reservoir hosts, particularly rodents. Climate variability, habitat alteration, agricultural expansion, livestock movement, urbanization, and other anthropogenic pressures can modify these transmission systems and create new opportunities for pathogen spillover. Effective prevention and control therefore require integrated surveillance that encompasses human disease, animal populations, vectors or wildlife reservoirs, and environmental conditions. Advances in molecular diagnostics, genomic epidemiology, ecological modeling, remote sensing, and climate-based forecasting provide valuable opportunities for improving early detection and outbreak preparedness. To reduce the burden of these zoonotic viral diseases, a sustained collaboration among human and veterinary health professionals, ecologists, entomologists, environmental scientists, and public health authorities is required. Therefore, a coordinated One Health approach is essential for anticipating emerging threats, strengthening preparedness, and protecting human, animal, and ecosystem health.