[en] [en] PURPOSE: Inulin-type fructans (ITF) are fermentable dietary fibres (DF) that can confer beneficial metabolic health effects through changes in the gut microbiota. Many papers suggest that complex food rich in DF could be more relevant than purified DF in terms of health effect. We compared the prebiotic effect of natural source of inulin (scorzonera) versus native inulin extracted from chicory root in a model of obesity.
METHODS: Mice were fed during 6 weeks a low-fat (LF), high-fat (HF) or high-fat diet enriched with either purified inulin from chicory root (Inu) or lyophilized scorzonera (Sco), with the same amount of ITF intake (10%) versus a non-fermentable fibre (cellulose). Metabolic parameters were correlated with the gut microbiome composition (16S rRNA gene sequencing).
RESULTS: Both inulin sources reduced food intake without significantly modifying body weight gain or adiposity compared to HF. Purified inulin and lyophilized scorzonera differentially modulate the gut physiology and microbiota. Both inulin and scorzonera shifted global gut microbial composition from HF group, decreased members of Desulfovibrionaceae and boosted bifidobacteria level. Some effects were specific to Sco group, such as the increase of Akkermansia and the decrease of Bacteroides, that correlated to biological outcomes. Inu improved hepatic steatosis whereas scorzonera boosted intestinal immunity markers and antimicrobial peptides expression, and increased intestinal crypt depth.
CONCLUSION: Differences occur between natural edible versus isolated sources of ITF. Both sources of inulin shifted the gut microbiota, but differently affected intestinal and lipid homeostasis. This study highlights the importance of food matrix and origins of fructans for their use in the context of metabolic disorders.
Disciplines :
General & internal medicine
Author, co-author :
Neyrinck, Audrey M ; Metabolism and Nutrition Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Université catholique de Louvain, B-1200, Brussels, Belgium
Rodriguez, Julie ; Metabolism and Nutrition Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Université catholique de Louvain, B-1200, Brussels, Belgium
Sánchez, Candido Robles; Metabolism and Nutrition Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Université catholique de Louvain, B-1200, Brussels, Belgium
Autuori, Manon; Metabolism and Nutrition Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Université catholique de Louvain, B-1200, Brussels, Belgium
Cani, Patrice D ; Metabolism and Nutrition Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Université catholique de Louvain, B-1200, Brussels, Belgium ; Walloon Excellence in Life Sciences and BIOtechnology (WELBIO) Department, WEL Research Institute, Wavre, Belgium ; Institute of Experimental and Clinical Research (IREC), UCLouvain, Université catholique de Louvain, B-1200, Brussels, Belgium
Bindels, Laure B ; Metabolism and Nutrition Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Université catholique de Louvain, B-1200, Brussels, Belgium ; Walloon Excellence in Life Sciences and BIOtechnology (WELBIO) Department, WEL Research Institute, Wavre, Belgium
Bindelle, Jérôme ; Université de Liège - ULiège > Département GxABT > Animal Sciences (AS)
Delzenne, Nathalie M ; Metabolism and Nutrition Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Université catholique de Louvain, B-1200, Brussels, Belgium. nathalie.delzenne@uclouvain.be
Language :
English
Title :
Interest of inulin in obesity: comparison of the prebiotic effect of edible-food sources versus purified inulin from chicory root.
Publication date :
05 April 2025
Journal title :
European Journal of Nutrition
ISSN :
1436-6207
eISSN :
1436-6215
Publisher :
Springer Science and Business Media Deutschland GmbH
SPW EER - Service Public de Wallonie. Economie, Emploi, Recherche F.R.S.-FNRS - Fonds de la Recherche Scientifique
Funding text :
We would like to thank Am\u00E9lie Flandin, Remi Selleslagh, V\u00E9ronique Allaeys, Isabelle Blave and Bouazza Es Saadi for their precious implication in the study.This study was supported by the Service Public de Wallonie (SPW- EER, convention FOOD4GUT 1318148) and the Fonds de la Recherche Scientifique (FRS)\u2010FNRS (PDR T.0085.24). LBB is a Collen-Francqui Research Professor and grateful for the support of the Francqui Fondation.. P.D.C. is honorary research director at FRS-FNRS (Fonds de la Recherche Scientifique) and recipients of grants from FNRS (FRFS-WELBIO: WELBIO-CR-2022A-02, EOS: program no. 40007505, PDR: T.0032.25).
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